| 慢性肾衰患者不同透析膜血透时脂质过氧化变化及其临床意义 |
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| 引用本文： | 吴玉琼,娄探奇.慢性肾衰患者不同透析膜血透时脂质过氧化变化及其临床意义[J].中国现代医学杂志,1999,9(8):6-7. |
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| 作者姓名： | 吴玉琼 娄探奇 |
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| 作者单位： | 中山医科大学第三附属医院肾内科!广州510630 |
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| 摘 要： | 为探讨慢性肾衰患者不同透析膜透析时氧自由基的氧化损伤，对维持性血透病人使用铜仿膜，聚砜膜及血仿膜透析，分别检测透析前，后血浆和红细胞脂质过氧化物，超氧化物歧化酶及全血谷胱甘肽过氧化物酶活性，并与健康组对照。
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| 关 键 词： | 慢性 肾功能衰竭 脂质过氧化物 SOD 血液透析 |
INVESTIGATION OF LIPID PEROXIDE CONTENT IN CHRONIC RENAL FAILURE PATIENTS HEMODIALYZED WITH DIFFERENT MEMBRANES |
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| Wu Yuqiong,Lou Tanqi,Lin Guizhen,He Xiuying Depatment of Nephrology,Third Affiliated Hospital,Sun Yat-sen University of Medical Sciences,Guangzhou.INVESTIGATION OF LIPID PEROXIDE CONTENT IN CHRONIC RENAL FAILURE PATIENTS HEMODIALYZED WITH DIFFERENT MEMBRANES[J].China Journal of Modern Medicine,1999,9(8):6-7. |
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| Authors: | Wu Yuqiong Lou Tanqi Lin Guizhen He Xiuying Depatment of Nephrology Third Affiliated Hospital Sun Yat-sen University of Medical Sciences Guangzhou |
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| Institution: | Wu Yuqiong,Lou Tanqi,Lin Guizhen,He Xiuying Depatment of Nephrology,Third Affiliated Hospital,Sun Yat-sen University of Medical Sciences,Guangzhou510630 |
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| Abstract: | Objective: To investigate the possible oxidative injuries to chronic renal failuer patients during hemodialysis with different membranes.Methods:The levels of lipid peroxide(LPO) and superoxide dismutase(SOD) in plasma and red cell,gultathione peroxidase(GPX) in whole blood samples of hemodialyzed patients were examined respectively before and after being hemodialyzed with cupophane,polysulphone and hemophan membranes,and were compared with those of the health controls. Results:There was a significant increase of LPO level and a decrease of SOD activity after being dialyzed with cupophane membrane, while no significant difference was observed in the groups dialyzed with polysulhone and hemophan membranes.Conclusion:The results suggest that the application of polysulphone and hemophan membranes for long term hemodialysis is beneficial to prevent and cure the syndrome caused by the increase of peroxide radicals. |
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| Keywords: | Hemodialysis Lipid peroxide Superoxide dismutase Gultathione peroxidase |
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