| 心境稳定剂的药物相互作用 |
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| 引用本文： | 左笑丛,刘玉兰,吴翠芳,张毕奎.心境稳定剂的药物相互作用[J].中国新药与临床杂志,2007,26(12):934-938. |
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| 作者姓名： | 左笑丛 刘玉兰 吴翠芳 张毕奎 |
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| 作者单位： | 中南大学湘雅三医院,药剂科,湖南,长沙,410013 |
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| 摘 要： | 心境稳定剂在临床应用中普遍存在联合用药现象,不仅有多种心境稳定剂的合用,也有与抗精神病药、抗抑郁药的合用,还有心境稳定剂本身作为辅助用药等问题。目前广泛使用的心境稳定剂包括锂盐与抗癫痫药物,而多药联用就有可能在药物体内过程的各环节发生相互作用。本文将从药物在体内的分布、代谢与排泄等药动学过程及药效学方面来综述心境稳定剂与其他可能合用药物的相互作用,以期为临床合理选药提供参考。
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| 关 键 词： | 药物相互作用 抗惊厥药 抗抑郁药 抗精神病药 心境稳定剂 |
| 文章编号： | 1007-7669（2007）12-0934-05 |
| 收稿时间： | 2007-07-20 |
| 修稿时间： | 2007-11-15 |
Drug interactions of mood stabilizers |
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| zuo Xiao-cong,LIU Yulan,WU Cui-fang,ZHANG Bi-kui.Drug interactions of mood stabilizers[J].Chinese Journal of New Drugs and Clinical Remedies,2007,26(12):934-938. |
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| Authors: | zuo Xiao-cong LIU Yulan WU Cui-fang ZHANG Bi-kui |
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| Abstract: | Mood stabilizers are generally used as combination with another mood stabilizer, antipsychotic drugs, antidepressive drugs, or other drugs in the clinical application. Lithium salt and antiepileptic drugs are extensively used as mood stabilizers. Drug interactions may be generated in the physiological disposition while multiple drugs jointing. This article reviews the interactions of mood stabilizers with other combined drugs in the aspects of pharmacokinetics and pharmacodynamics so as to provide effective drug information for clinic. |
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| Keywords: | drug interactions anticonvulsants antidepressive agents antipsychotic agents mood stabilizers |
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