不同方式的睾丸切除术在进展期前列腺癌治疗中的疗效比较 |
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引用本文: | 高远,苏顺业,刘鲁东,臧运江,王沈阳,张明荣,周全,曾绍文,乔梁.不同方式的睾丸切除术在进展期前列腺癌治疗中的疗效比较[J].内分泌外科杂志,2011,5(5):340-342. |
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作者姓名: | 高远 苏顺业 刘鲁东 臧运江 王沈阳 张明荣 周全 曾绍文 乔梁 |
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作者单位: | 261041,山东省潍坊市人民医院泌尿外科 |
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摘 要: | 目的比较保留附睾的睾丸切除术(A组)与传统睾丸切除术(B组)在进展期前列腺癌治疗中的疗效,探讨睾丸去势治疗的最佳选择方式。方法进展期前列腺癌60例,A、B组各30例。均在局麻下行单切口双侧睾丸切除术,术后第1天起口服非类固醇类雄激素阻断剂。分别于术前、术后1周及1、3、6、9、12个月,观察2组血清总睾酮、前列腺特异性抗原(PSA)变化;了解患者手术满意度等。结果去势术后12个月,A、B组血清睾酮平均水平分别为0.2nmol/L(95%置信区间0.1~0.9nmol/L)、0.3nmol/L(95%置信区间0.2~0.9nmol/L),均〈1.9nmol/L,2组均数比较,P〉0.05;A组PSA平均值0.22ng/ml,B组0.27ng/ml,2组均数比较,P〉0.05。问卷调查示A组满意度为96.7%(29/30),B组为53.3%(16/30)。结论2种睾丸切除术在进展期前列腺癌治疗中疗效无明显差异,但保留附睾的睾丸切除术、附睾成形术有助于满足患者的阴囊外观形态和心理需要。
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关 键 词: | 前列腺肿瘤 睾丸 附睾 睾丸切除术 睾酮 |
Assessment of different orchiectomy for patients with advanced prostate cancer |
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Authors: | GAO Yuan SU Shun-ye LIU Lu-dong ZANG Yun-jiang WANG Shen-yang ZHANG Ming-rong ZHOU Quan ZENG Shao-wen QIAO Liang |
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Institution: | . (Department of Urology, Weifang People's Hospital, Weifang 261041, China) |
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Abstract: | Objective To compare epididymis-sparing orchiectomy (group A) with traditional orchiectomy (group B ) in patients with advanced prostate cancer,and to evaluate which procedure is better.Methods A total of 60 cases of advanced prostate cancer patients were enrolled,with 30 cases in group A and 30 cases in group B.They were given oral anti-androgen from 1 day after castration.Serum level of testosterone and prostatic specific antigen (PSA) was detected before castration,and 1 week,1,3,6,9 and 12 months after castration.Patient satisfaction was also evaluated.Results On time point of 12 months after castration,the average level of serum testosterone was 0.2 nmol/L (95 % confidence interval,0.1 ~ 0.9 nmol/L) in group A and 0.3 nmol/L (95% confidence interval,0.2 ~ 0.9 nmol/L) in group B (P >0.05 ) ; the average value of PSA was 0.22 ng/ml in group A and 0.27 ng/ml in group B (P >0.05 ) ; patient satisfaction rate was 96.7% (29/30) in group A and 53.3% (16/30) in group B.Conclusions No significant difference of testosterone level and PSA is found between the 2 groups.However,epididymis-sparing orchiectomy meets the psychological needs better because it helps to maintain the appearance of the scrotum through epididymis preservation and epididymoplasty. |
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Keywords: | Prostatic neoplasms Testis Epididymis Orchiectomy Testosterone |
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