Clinical Trials of a New Anticancer Drug, 1-Hexylcarbamoyl-5-fluorouracil |
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Authors: | OKABAYASHI KENZO; KOYAMA YASUO; MARUYAMA KEIICHI; OKAZAKI NOBUO; SAKANO TERUO; ISE TORU |
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Institution: | 1Department of Surgery Tokyo
2Internal Medicine Tokyo
3Pediatrics, National Cancer Center Hospital Tokyo |
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Abstract: | 1-Hexylcarbamoyl-5-fluororacil (HCFU) is a new anticancer drugdiscovered as a derivative of 5-fluorouracil (5-FU). In thisstudy, peculiar types of toxicity such as a hot sensation, pollakisuriaand urgency to defecate appeared in 23% of the patients, whilegastrointestinal, hematological, hepatic and renal toxicitywas very rarely observed. Blood levels of the HCFU fractionand 5-FU were maintained at high concentrations until four hoursafter administration. In a study of 30 evaluable cases withtumors in the various primary sites, good responses were obtainedin an infant with a recurrence of hepatoblastoma and in a patientwith recurrent cancer of the stomach. |
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