| 三唑醇类化合物的合成及抗真菌活性 |
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| 引用本文： | 甘亚,吕丁,刘剑,田敏.三唑醇类化合物的合成及抗真菌活性[J].中国药物化学杂志,2001,11(2):85-88. |
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| 作者姓名： | 甘亚 吕丁 刘剑 田敏 |
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| 作者单位： | 四川抗菌素工业研究所, |
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| 基金项目： | 国家青年新药基金项目(No.96-901-05-128) |
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| 摘 要： | 本文根据三唑醇类抗真菌化合物构效关系研究的结果提示,以氟康唑为先导物,设计合成了11个未见文献报道的新三唑醇类化合物,经体外抗真菌活性筛选,以氟康唑为参照物,其中四个化合物表现出良好的抗真菌活性.
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| 关 键 词： | 三唑醇 合成 抗真菌活性 |
| 文章编号： | 1005-0108(2001)02-0005-04 |
Synthesis and Antifungal
Activity of Novel Triazole Alcohols |
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| GAN Ya,LU Ding,LIU Jian,TIAN Min.Synthesis and Antifungal
Activity of Novel Triazole Alcohols[J].Chinese Journal of Medicinal Chemistry,2001,11(2):85-88. |
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| Authors: | GAN Ya LU Ding LIU Jian TIAN Min |
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| Abstract: | Based on the result of QSAR which was studied among a series of triazole antifungal agents,11 new compounds were designed and synthesized,and they were identified with MS,IR, 1H NMR.Screened in vitro and compared to control compound fluconazole,four of those showed good antifungal activity. |
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| Keywords: | triazole alcohol synthesis antifungal activity |
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