Effects of gold sodium thiomalate,cyclosporin A,cyclophosphamide, and placebo on collagen-induced arthritis in rats |
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| Authors: | Grant W. Cannon M.D. Shawna McCall Barry C. Cole Lesley A. Radov John R. Ward Marie M. Griffiths |
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| Affiliation: | (1) Veterans Affairs Medical Center, University of Utah School of Medicine, 500 Foothill Dr., 84148 Salt Lake City, UT, USA;(2) Division of Rheumatology, Department of Internal Medicine, University of Utah School of Medicine, 500 Foothill Dr., 84148 Salt Lake City, UT, USA;(3) Fison Pharmaceuticals, Rochester, New York, USA |
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| Abstract: | The prophylactic and therapeutic effects of gold sodium thiomalate, cyclosporin A, cyclophosphamide, and placebo on collagen-induced arthritis (CIA) were evaluated in DA rats. Prophylactic treatment with cyclosporin A and cyclophosphamide suppressed the arthritis incidence, clinical inflammation, destructive bone changes, and development of anti-collagen antibody in DA rats subsequently injected with porcine type-II collagen. Therapeutic treatment with cyclosporin A and cyclophosphamide had a definite suppression on established CIA when started 21 days after the initial collagen injection, but the suppression was less marked than that of prophylactic treatment. Gold had no impact on CIA in DA rats when administered either prophylactically or therapeutically. |
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