Recombinant interleukin-1 stimulates prostaglandin E2 production by osteoblastic cells: Synergy with parathyroid hormone |
| |
| Authors: | Dr. Dimitris N. Tatakis Gerald Schneeberger Rosemary Dziak |
| |
| Affiliation: | (1) Department of Oral Biology, School of Dental Medicine, State University of NY at Buffalo, 14214 Buffalo, New York, USA |
| |
| Abstract: | Summary Recombinant mouse IL-1 (Interleukin-1) has been shown to be capable of stimulating prostaglandin E2 (PGE2) production by isolated rat osteoblastic cells in a dose-dependent manner. The rapidity of the effect (1 hour) and the potency of IL-1 (5×10−12 M) in producing this effect suggest that IL-1 may exert some of its effects on bone via PGE2. Parathyroid hormone (PTH) appears to have a strong synergistic effect with IL-1. These data further substantiate the role of IL-1 in bone physiology. |
| |
| Keywords: | Interleukin-1 Osteoblast Prostaglandin Parathyroid hormone |
| 本文献已被 SpringerLink 等数据库收录！ |
