Plasma somatomedin-C levels in systemic sclerosis |
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| Authors: | M.J. ROTHE R.D. ALTMAN V. FALANGA |
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| Affiliation: | Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Florida 33101. |
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| Abstract: | We have measured the plasma levels of somatomedin-C (SM-C) or insulin-like growth factor I (IGF-I) in 13 patients with progressive systemic sclerosis (PSS) and age and sex matched healthy controls. We found the plasma SM-C levels to be within normal limits in all the patients. Thus, if somatomedin-C plays a role in the pathogenesis of PSS, it is more likely to be at the fibroblast receptor level or in the synthetic response of fibroblasts to SM-C. |
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