卡维地洛对中国高血压病人的疗效及安全性观察

目的：评价卡维地洛对中国高血压病人的降压疗效及安全性。方法：按照1999年WHO高血压的诊断标准．将62例门诊高血压病人随机分为A组(卡维地洛组)42例，B组(比索洛尔组)20例，服用安慰剂2周后进行药物治疗8周．治疗前后测定血压、生化、血脂、血常规。结果：治疗后血压A组SBP下降18mmHg，DBP下降13．3minHg；B组SBP下降24．5mmHg.DBP下降20．3mmHg，两组间血压下降无显著差异。并且卡维地洛组在降低低密度脂蛋白方面优于比索洛尔组。结论：卡维地洛对中国轻、中型高血压病人使用可达到全日有效的降压效果，无明显不良反应。

The Effect and Safety of Carvedilol in Chinese Hypertension Patients

Objective: To assess the antihypertension effect and safety of Carvedilol in Chinese patients. Methods:According to the diagnostic criterion of hypertension in 1999,62 outpatients with essential hypertension were enrolled into this study,and divided into two groups:group A(42 cases were given Carvedilol) and group B(20cases were given Bisoprolol).After 2 weeks of placebo, all patients had taken above drugs for 8 weeks .all patients were performed laboratory test and clinical blood pressure at the beginning and the end of treatment.Results: There were no difference in antihypertensive effect between the two group: in group A the SBP was lowered 18mmHg, DBP was lowered 13.3mmHg, in group B SBP was lowered 24.5mmHg,DBP was lowered 20.3mmHg, meanwhile the influence of lipid of serum A group is better than B group. Conclusion:Carvedilol is effective and safety to Chinese hypertension patients with mild to moderate essential hypertension.