阿托品对青光眼术后前房深度的影响

目的 观察青光眼滤过术后阿托品对前房深度的影响.方法 将30例(42只眼)原发性闭角型青光眼患者,随机分成两组,阿托品组(20只眼),青光眼术后每天用1%阿托品眼膏散瞳:非阿托品组(22只眼),青光眼术后用短效散瞳剂(0.25%托比卡胺眼液)活动瞳孔.术前及术后1d、3d、7d、14d、30d及90d测量眼压;术前及术后每天在裂隙灯下观察前房深度;术前及术后7d、14d、30d用超声生物显微镜(UBM)测量中央前房深度.结果 裂隙灯下两组青光眼术后浅前房的发生率:阿托品组为10%,非阿托品组为13.6%(P>0.05);UBM 检测结果:术后7d、14d、30d不同时间段中,阿托品组前房深度均较非阿托品组深,但差异无统计学意义(P>0.05).结论 原发性闭角型青光眼术后使用阿托品散瞳对前房深度没有重大影响,不能预防浅前房发生,但可用于浅前房的治疗.

Effect of atropine on the anterior chamber depth in glaucomatous patients after trabeculectomy

Objective To investigate the effects of postoperative atropine on anterior chamber depth. Methods Two groups of patients who were diagnosed primary open angle glaucoma underwent primary trabeculectomy were randomized to atropine or no atropine group.Slit-lamp was used to exam the patients before surgery and everyday after surgery.Intraocular pressure was monitored before surgery and on postoperative day 1, 3, 7, 14, 30, and 90.Central chamber depths were measured using UBM before surgery and on postoperative days 7, 14, and 30.Results The incidence rates of shallow anterior chamber of atropine group and no atropine group were 10% and 13.6%, respectively (P>0.05).Compared with no atropine group, the depths of anterior chamber were deeper, but there was no statistically significant difference between the two groups at any time (P>0.05).Conclusions This study shows no statistically significant deepening of the anterior chamber with atropine.Routine atropine use after trabeculectomy may not necessary to reduce incidence rate of shallowing of anterior chamber, but it may useful to deepen anterior chamber in patients with a shallow anterior chamber after trabeculectomy.