多肿瘤标志物蛋白芯片检测在结直肠癌复发监测中的应用价值

目的：研究多肿瘤标志物蛋白芯片（Ｃ-１２芯片）检测在结直肠癌复发监测中的应用价值。方法：采用Ｃ-１２芯片检测系统检测７９例结直肠癌术后患者（包括复发组４０例和无复发组３９例）血清中１２种肿瘤标志物（ＣＡ１９９、ＮＳＥ、ＣＥＡ、ＣＡ２４２、Ｆｅｒｒｉｔｉｎ、β-ＨＣＧ、ＡＦＰ、ｆ-ＰＳＡ、ＰＳＡ、ＣＡ１２５、ＣＡ１５３及ＨＧＨ）的水平。结果：（１）术后复发组与无复发组相比，Ｃ-１２芯片阳性率之间有显著性差异（χ２＝５０.７３，Ｐ＜０.００１），复发组中ＣＡ１９９、ＣＥＡ和ＣＡ２４２的检测阳性率相对较高，分别为５７.５０％、７０.００％和５０.００％。（２）复发组与无复发组相比，ＣＡ１９９、ＣＥＡ、ＣＡ２４２、Ｆｅｒｒｉｔｉｎ、ＣＡ１２５和ＣＡ１５３检测阳性率和检测结果均有显著性差异（Ｐ＜０.０５）；（３）ＣＡ１９９、ＣＥＡ和ＣＡ２４２联合检测的阳性率最高，可达到８７.５０％，与ＣＡ１９９、ＣＡ２４２联合检测相比，对术后复发患者的检测阳性率差异显著（Ｐ＜０.０１）。结论：（１）多肿瘤标志物蛋白芯片检测系统对结直肠癌的复发监测具有较高的临床应用价值。（２）ＣＡ１９９、ＣＥＡ和ＣＡ２４２联合检测可能是一种既经济又有效的结直肠癌术后复发监测组合。

The clinical value of multiple tumor marker protein chip system in evaluating recidivation of colorectal cancer

Objective：To evaluate the effect of muhiple tumor marker protein chip in evaluating recidivation of colorectal cancer. Methods：The serum levels of 12 tumor makers were measured in 79 postoperative patients with colorectal cancer（ including 40 recurrence patients and 39 non-recurrence patients）. Results：The recurrence patients had significantly higher positive rate than that of the non-recurrence patients （X2 = 50.73, P 〈 0. 001 ）. The positive rates of CA199, CEA and CA242 were 92. 50%, 50.00% and 23.68% in recurrence patients, respectively. The positive rates and serum levels of CA199, CEA, CA242, Ferritin, CA125 and CA153 in the recurrence patients had significant difference compared with that in the non-recurrence patients （ P 〈 0. 05 ）. The combination of CA199, CEA and CA242 had the hignest positive rate（87.50% ）. The positive rates of the combination of CA199,CEA and CA242 to diagnose the recurrence of colorectal cancer had significant difference compared with that of the combination of CA199 and CA242 （P 〈 0. 01 ）. Conclusion ：The Multi-tumor marker protein chip detective system had valid value of clinical application in the evaluate recidi- vation of colorectal cancer. The combination of CA199 ,CEA and CA242 may be the economical and effective tumor markers in the evaluate postoperative recidivation of colorectal cancer.