脑胶质瘤组织中TGF-β1 和CD105 蛋白表达及其相关性

 目的 探讨胶质瘤组织中转化生长因子-β1（TGF-β1）和CD105蛋白表达的相互关系及其临床意义。方法 应用免疫组化SP法检测70例胶质瘤和10例正常脑组织中TGF-β1和CD105的表达水平，并分析它们与胶质瘤临床病理因素的关系。结果 TGF-β1和CD105表达均与胶质瘤病理分级相关（P〈0．01），与患者的性别、年龄及肿瘤大小无明显关系（P〉0．05）。TGF-β1阳性表达组的MVD（37．68±4．91）显著高于阴性表达组（30．01±5．26），（P〈0．01），且TGF-131表达与CD105-MVD呈正相关（r=0．6547，P〈0．05）。结论 TGF-β1和CD105高表达共同促进胶质瘤恶性增殖与血管形成。

Expression and Correlation of TGF-β1 and CD105 in Glioma Tissues

Objective 　To investigate the possible relationship between the expressions of TGF-β1 and CD105 in human gliomas and clinical significance. Methods 　The expressions of TGF-β1 and CD105 were examined by SP Immunohistochemical staining in 70 human glioma specimens and in 10 normal human brain tissue specimens ,and their relationship s with clinic-pathological factors was also analyzed. Results The expressions of TGF-β1 and CD105 were closely associated with pathological grade ( P < 0. 01) ,but theirs expression in gliomas had no obvious relationship to the sexes , ages and sizes of tumor ( P > 0. 05) .The MVD values (37. 68 ±4. 91) in TGF-β1 positive groups was significantly higher than those (30. 01 ±5. 26) in negative groups ( P < 0. 01) ,and The expressions of TGF2β1 and CD105 were positively correlated ( r = 0. 6547 , P < 0. 05) . Conclusion 　The cojioned overexpressions of TGF-β1 and CD105 may promote malignant proliferation and angiogenesis of glioma.