| 盐酸丁咯地尔羟丙基甲基纤维素骨架片的实验研究 |
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| 引用本文： | 朱希强,翟光喜,张斌. 盐酸丁咯地尔羟丙基甲基纤维素骨架片的实验研究[J]. 中国现代应用药学, 2002, 19(3): 182-185 |
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| 作者姓名： | 朱希强 翟光喜 张斌 |
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| 作者单位： | 1. 济南,250001,济南铁路局中心医院药剂科
2. 山东大学药学院 |
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| 摘 要： | 目的：研制盐酸各地尔HPMC缓释骨架片。方法：湿颗粒法压片，正交实验设计考察HPMC的用量、粘度及粘和剂对药物体外释放速率的影响。结果：盐酸丁咯地尔骨架片的体外释放行为符合Higuchi方程；粘和剂种类和HPMC的用量对制剂的释药速率有显著性影响。结论：盐酸丁咯地尔HPMC骨架片有良好的缓释性。
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| 关 键 词： | 盐酸丁咯地尔 羟丙基甲基纤维素 骨架片 实验研究 正交实验设计 药物体外释放速率 |
Study on HPMC Matrix Tablets of Buflomedil Hydrochloride |
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| Zhu Xiqiang(Zhu XQ,Zhai Guanxi(Zhai GX,Zhang Bin(Zhang B. Study on HPMC Matrix Tablets of Buflomedil Hydrochloride[J]. The Chinese Journal of Modern Applied Pharmacy, 2002, 19(3): 182-185 |
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| Authors: | Zhu Xiqiang(Zhu XQ Zhai Guanxi(Zhai GX Zhang Bin(Zhang B |
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| Abstract: | OBJECTIVE:To study the hydroxypropylmethylcellulose (HPMC) matrix tablets of Bufiomedil Hydrochloride (BH).METHOD:The tablets were prepared by the method of wet granule.The effects of the amount,viscosity of HPMC and species of bonding agents on the BH release rate were investigated with orthogonal design.RESULTS:The BH release behavior followed Higuchi equation and the amount of HPMC and species of bonding agent could significantly affect the BH release rate from matrix tablets.CONCLUSION:The HPMC matrix tablets of BH had a well sustained release. |
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| Keywords: | Bufiomedil Hydrochloride orthogonal design matrix tablet Hydroxypropylmethylcellulose |
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