| Wnt信号参与压力超负荷诱导的小鼠心力衰竭过程 |
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| 引用本文： | 马桢,;黄雄,;汤彦,;孙维兰,;张玉荣,;胡立志,;叶勇,;邹云增. Wnt信号参与压力超负荷诱导的小鼠心力衰竭过程[J]. 中国分子心脏病学杂志, 2014, 0(6): 1153-1156 |
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| 作者姓名： | 马桢, 黄雄, 汤彦, 孙维兰, 张玉荣, 胡立志, 叶勇, 邹云增 |
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| 作者单位： | [1]上海市复旦大学附属中山医院青浦分院,201700; [2]上海市浦东新区浦南医院,200125; [3]上海市中山医院心血管疾病研究所,200032 |
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| 基金项目： | 上海市局级课题（ZK2012A37）;上海市卫生局青年课题（20124y111） |
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| 摘 要： | 目的通过检测wnt11、WIF-1及β-catenin在压力超负荷心力衰竭小鼠中的表达探索wnt信号在心力衰竭发生过程中的作用。方法主动脉缩窄法（transverse aortic constriction,TAC）建立C57/BL6小鼠心衰模型,假手术组为对照组。彩色多普勒采集心脏指标,取建模前后的血浆样本及心肌样本,测定血液中wnt11、WIF-1浓度及心肌组织中wnt11、WIF-1及β-catenin表达情况。结果与假手术组比较,TAC组小鼠wnt11、β-catenin的表达明显高于假手术组,而WIF-1的表达明显下降。结论 wnt途径信号分子参与压力超负荷介导的心力衰竭发生发展过程,相关生物标记物可能对心力衰竭的治疗有指导意义。
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| 关 键 词： | wnt11 WIF-1 β-catenin 心力衰竭 主动脉缩窄术 |
Wnt Signaling Pathway is Involved in the Pressure-induced Heart-failure Mouse Model |
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| Affiliation: | MA Zhen,HUANG Xiong,TANG Yan,SUN Weilan,ZHANG Yurong,HU Lizhi,YE Yong,ZOU Yunzeng(1 Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, 201700, China. 2 Pudong Punan hosipital, Shanghai, 200125, China. 3 Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai,200032,China.) |
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| Abstract: | Objective To explore the patent role of wnt signaling pathway involved in the pathological process of heart-failure mouse model through wnt11,WIF-1 and beta-catenin. Methods Pathological heart-failure（HF） mouse model was set up by transverse aortic constriction（TAC）. Male C57/BL6 mice were subjected to either sham or TAC surgery.Transthoracic echocardiography was performed on both groups before and after HF.Wnt11,WIF-1 and beta-catenin were detected out of the blood and myocardium samples. Results Wnt11 and beta-catenin were up-regulated,while WIF-1 was attenuated in the TAC group compared with sham. Conclusion wnt signaling pathway is involved in the pressure-induced heart-failure mouse model.Such biomarkers could be helpful in revealing new factors in HF therapeutic area. |
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| Keywords: | Wnt11 WIF-1 β-catenin Heart Failure Transverse Aortic Constriction |
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