A new class of isoxazole derivatives: the M 1-9 series of compounds with immunotropic activity |
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Authors: | Maczyński Marcin Zimecki Michał Ryng Stanisław |
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Institution: | Wroc?aw Medical University, Faculty of Pharmacy, Department of Organic Chemistry, 50-137 Wroc?aw, 9 Grodzka Str., Poland. marcinm@chorg.am.wroc.pl |
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Abstract: | The isoxazole derivatives are interesting objects for synthesis in the search for various sorts of biological activity. Looking for more active immunomodulators we synthesized a series of 5-amino-3-methyl-4-isoxazolecarboxylic acid semicarbazides and thiosemicarbazides in the reaction of 5-amino-3-methyl-4-isoxazolecarboxylic acid hydrazide with isocyanates and isothiocyanates. The biological effect of these compounds on the proliferative response of human mononuclear peripheral blood cells to phytohemagglutinin A (PHA) was described. |
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