| 类视黄醇对呼吸道感染患儿细胞因子分泌的影响 |
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| 引用本文： | 张俊红,钱幼琼,郑德元.类视黄醇对呼吸道感染患儿细胞因子分泌的影响[J].营养学报,2001,23(4):302-304. |
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| 作者姓名： | 张俊红 钱幼琼 郑德元 |
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| 作者单位： | 1. 北京空军总医院儿科,
2. 华西医科大学附二院儿科, |
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| 摘 要： | 目的 : 观察了视黄醇、视黄酸、维生素 A醋酸酯三种类视黄醇在体外对反复呼吸道感染 (RRI)患儿外周血单个核细胞 (PBMC)中的淋巴细胞分泌白细胞介素 2 (IL- 2 )及单核细胞分泌白细胞介素 1 (IL- 1 )的影响。方法 : 测定 RRI患儿 PBMC分泌 IL- 1、IL- 2活性以及在 1 0 -9mol/ L浓度时上述三种类视黄醇作用下分泌 IL- 1、IL- 2活性 ,与正常儿童相比较。结果 : RRI患儿 PBMC分泌 IL- 1、IL- 2活性较正常儿童低 ,但经类视黄醇刺激后明显增高 ,可达到正常水平。三种类视黄醇均能明显促进 IL - 1、IL- 2分泌 ,其中视黄酸作用最强 ,VA醋酸酯次之 ,视黄醇最弱。结论 : RRI患儿 PBMC分泌 IL - 1、IL - 2活性经类视黄醇刺激后能明显增高 ,达到正常水平。
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| 关 键 词： | 类视黄醇 反复呼吸道感染 白细胞介素1 白细胞介素2 |
| 文章编号： | 0512-7955(2001)04-0302-04 |
| 修稿时间： | 2001年6月12日 |
EFFECTS OF RETINOIDS ON THE PRODUCTION OF CYTOKINES OF PBMC FROM THE CHILDREN WITH RECURRENT RESPIRATORY INFECTION |
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| ZHANG Jun-hong,QIAN You-qiong,ZHENG De-yuan.EFFECTS OF RETINOIDS ON THE PRODUCTION OF CYTOKINES OF PBMC FROM THE CHILDREN WITH RECURRENT RESPIRATORY INFECTION[J].Acta Nutrimenta Sinica,2001,23(4):302-304. |
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| Authors: | ZHANG Jun-hong QIAN You-qiong ZHENG De-yuan |
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| Abstract: | Objective: To study the effects of retinoids (retinol? retinoic acid? retinyl acetate) in vitro on the production of interleukin 1 (IL-1)? interleukin 2 (IL-2) of peripheral blood mononuclear cells (PBMC) from the children with recurrent respiratory infection (RRI). Methods: The activities of IL-1? IL-2 of the PBMC from RRI children and the changes of IL-1? IL-2 activities after cultured with 10 -9 mol/L retinoids were measured. Results: The activities of IL-1? IL-2 of PBMC from RRI children were lower than normal control and could be restored to normal level after cultured with retinoids. Conclusion: The production of IL-1? IL-2 of PBMC from RRI children can be enhanced by retinoids and restored to normal. |
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| Keywords: | retinoids recurrent respiratory infection interleukin 1 interleukin 2 |
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