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Regional localization of polymorphic markers on chromosome 10 by physical and genetic mapping |
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| Authors: | C. G. P. MATHEW W. WAKELING E. JONES D. EASTON R. FISHER C. STRONG B. SMITH K. CHIN P. LITTLE Y. NAKAMURA T. B. SHOWS C. JONES P. J. GOODFELLOW S. POVEY B. A. J. PONDER |
| Affiliation: | Cancer Research Campaign Human Cancer Genetics Research Group, Institute of Cancer Research, Surrey/Department of Pathology, University of Cambridge, UK;Section of Epidemiology, Institute of Cancer Research, Surrey, UK;Department of Biochemistry, Imperial College of Science and Technology, London, UK;Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah, USA;Roswell Park Memorial Institute, Buffalo, New York, USA;Eleanor Roosevelt Institute, Denver, Colorado, USA;Department of Medical Genetics, University of British Columbia, Vancouver, Canada;MRC Human Biochemical Genetics Unit, The, Galton Laboratory, University College London, UK |
| Abstract: | The human vimentin gene and a random DNA segment (D10S39) were mapped to the short arm of human chromosome 10 by linkage analysis. A panel of somatic cell hybrids and monosomy cell-lines, which divide chromosome 10 into seven regions, was used to localize 10 polymorphic markers on this chromosome. The physical map locations obtained correlate well with linkage maps of chromosome 10. Two markers which have been shown to be closely linked to the gene for multiple endocrine neoplasia type 2A map distal to a translocation breakpoint in band 10qll.2 |
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