| S-腺苷蛋氨酸预处理对丙烯腈染毒小鼠急性毒性的影响 |
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| 引用本文： | 王世忠,黄一灵,陆婵,王苏华,邢光伟,张叶,陆荣柱.S-腺苷蛋氨酸预处理对丙烯腈染毒小鼠急性毒性的影响[J].江苏大学学报(医学版),2011,21(4):277-280. |
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| 作者姓名： | 王世忠 黄一灵 陆婵 王苏华 邢光伟 张叶 陆荣柱 |
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| 作者单位： | 江苏大学基础医学和医学技术学院预防医学系,江苏,镇江,212013 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 目的:探讨S-腺苷蛋氨酸(SAM)对丙烯腈(AN)染毒小鼠急性毒性的影响及可能机制.方法:雄性小鼠80只,随机分成8组,分别为空白对照(生理盐水)、单纯SAM对照、20 mg/kg 丙烯腈、40 mg/kg 丙烯腈、60 mg/kg 丙烯腈、SAM+20 mg/kg 丙烯腈、SAM+40 mg/kg丙烯腈、SAM+60...
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| 关 键 词： | 丙烯腈 S-腺苷蛋氨酸 细胞色素P450 2E1 还原性谷胱甘肽 |
Effects of S-adenosyl-L-methionine pretreatment on acute toxicity of acrylonitrile in mice |
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| WANG Shi-zhong,HUANG Yi-ling,LU Chan,WANG Su-hua,XING Guang-wei,ZHANG Ye,LU Rong-zhu.Effects of S-adenosyl-L-methionine pretreatment on acute toxicity of acrylonitrile in mice[J].Journal of Jiangsu University Medicine Edition,2011,21(4):277-280. |
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| Authors: | WANG Shi-zhong HUANG Yi-ling LU Chan WANG Su-hua XING Guang-wei ZHANG Ye LU Rong-zhu |
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| Institution: | WANG Shi-zhong,HUANG Yi-ling,LU Chan,WANG Su-hua,XING Guang-wei,ZHANG Ye,LU Rong-zhu(Department of Preventive Medicine,School of Medical Sciences and Laboratory Medicine,Jiangsu University,Zhenjiang Jiangsu 212013,China) |
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| Abstract: | Objective: To examine the potential protective effect of S-adenosyl-L-methionine(SAM) on acute acrylonitrile(AN) toxicity in mice.Methods: Eighty male Kun-ming mice were randomly divided into eight groups: normal control,SAM alone,20 mg/kg AN alone,40 mg/kg AN alone,60mg/kg AN alone,SAM+20 mg/kg AN,SAM+40 mg/kg AN and SAM+60 mg/kg AN.Mice were intraperitoneally(i.p.) preinjected with SAM at dosage of 50 mg/kg body weight every 12 h for 3 day,AN was i.p.administered at 12 h after the last SAM injection.The b... |
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| Keywords: | acrylonitrile S-adenosyl-L-methionine CYP2E1 GSH |
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