Age-adjusted incidence rates of synchronous liver metastases for stage IV colorectal cancer compared by sex,race, and age group |
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| Institution: | 1. Department of Surgery, City of Hope, Duarte, CA, USA;2. Department of Biostatistics, City of Hope, Duarte, CA, USA;1. Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA;2. Department of Surgery, Division of Surgical Oncology, University of Cincinnati College of Medicine, Cincinnati, OH, USA;1. Department of Gastroenterological Surgery II, Hokkaido University Faculty of Medicine, Sapporo, Japan;2. Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan;3. Division of Clinical Cancer Genomics, Hokkaido University Hospital, Sapporo, Japan;4. Genomics Unit, Keio Cancer Center, Keio University School of Medicine, Tokyo, Japan;5. Mitsubishi Space Software, Tokyo, Japan;6. Department of Cancer Pathology, Hokkaido University Faculty of Medicine, Sapporo, Japan;1. Department of Hepatopancreatobiliary Surgery, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol UK;2. Department of Pancreatic Surgery, University Hospitals Birmingham, UK;1. Division of Surgical Oncology, Department of Surgery University Hospitals Cleveland Medical Center, Cleveland, OH, USA;2. Division of Hematology/Oncology, Department of Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH, USA;3. Division of Transplant and Hepatobiliary Surgery, Department of Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH, USA;1. Department of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China;2. Department of General Surgery, Zhejiang Provincial Armed Police Corps Hospital, Hangzhou, Zhejiang, China;3. Department of Hepatopancreatobiliary Surgical Oncology, Military Institution of Hepatopancreatobiliary Surgery, The First Medical Center of Chinese People''s Liberation Army (PLA) General Hospital, Beijing, China;4. Department of Hepatobiliary Surgery, Affiliated Tumour Hospital of Guangxi Medical University, Nanning, Guangxi, China;5. Department of Hepatobiliary Surgery, Affiliated Hospital of Binzhou Medical College, Binzhou, Shandong, China;6. Department of General Surgery, Wenzhou People''s Hospital, Wenzhou, Zhejiang, China;7. Department of Hepatobiliary Surgery, LongYan First Hospital, Affiliated to Fujian Medical University, Longyan, Fujian, China;8. Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China;1. Department of Radiology, Section of Interventional Oncology - Microinvasive Therapy (SIP), Medical University of Innsbruck, Anichstr. 35, 6020, Innsbruck, Austria;2. Department of Radiology, The Royal Marsden Hospital, 203 Fulham Road, Chelsea, London, SW3 6JJ, UK;3. Department of Anesthesia, Medical University of Innsbruck, Anichstr. 35, 6020 Innsbruck, Austria;4. Department of Internal Medicine V, Medical University of Innsbruck, Anichstr. 35, 6020 Innsbruck Austria;5. Department of General, Visceral and Vascular Surgery, Salzkammergut Klinikum, D.Wilhelm Bock Strasse 1, 4840, Vöcklabruck Austria;6. Department of Visceral, Transplant and Thoracic Surgery, Center of Operative Medicine, Medical University of Innsbruck, Anichstr. 35, 6020, Innsbruck, Austria |
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| Abstract: | BackgroundReports on age-adjusted incidence rates of synchronous colorectal liver metastases (CRLM) among patients with stage IV colorectal cancer (CRC) are uncommon. This study presents in detail differences in CRLM incidence rates by sex, race, and age group.MethodsIncidence rates were obtained for adults diagnosed with Stage IV CRC in the years 2010–2015 using SEER. The ratio of CRLM incidence to stage IV CRC incidence was used to calculate the rate ratio.ResultsAverage age-adjusted CRLM incidence rate was 7.09 per 100,000 (95% CI, 6.93–7.26). CRLM incidence was higher at 8.68 (95% CI, 8.35–9.03) for males compared with 5.77 (95% CI, 5.64–5.90) for females. Highest incidence rate of 11.50 (95% CI, 10.43–11.76) was observed among Blacks. By age group the highest CRLM incidence was 24.42 (95% CI, 23.13–25.71) among adults age >75. The average rate ratio of CRLM to CRC incidence rate was 0.72 (95% CI, 0.71–0.73).ConclusionAge-adjusted incidence rates of synchronous CRLM are higher for men, Blacks, and older patients. The risk ratio indicates that 72% of stage IV CRC cases are at risk of synchronous CRLM, although CRLM risk appears to decline with age. |
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