Synergistic effect of aqueous extract of Telfaria occidentalis on the biological activities of artesunate in Plasmodium berghei infected mice |
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Authors: | OM Adegbolagun BO Emikpe IO Woranola Y Ogunremi |
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Affiliation: | 1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ibadan, Ibadan;2. Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria;3. Department of Clinical Pharmacy and Pharmacy Management, Faculty of Pharmacy, University of Ibadan, Ibadan |
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Abstract: | BackgroundResistance to most antimalarial drugs has encouraged the use of herbal preparations along with prescribed orthodox drugs.ObjectiveTo investigate effect of co-administration of aqueous extract of T. occidentalis leaves; commonly used as antimalarial and haematinic agent in Nigeria and artesunate using P. berghei animal model.MethodsIn vivo curative antiplasmodial effect of T. occidentalis (200mg/kg) alone and combination with artesunate (2mg/kg) were evaluated using albino mice infected with 106 parasitized erythrocytes of P. berghei intraperitoneally. The haematological parameters: haemoglobin level, red blood cells and white blood cells and packed cell volume were monitored using standard methods.ResultsAqueous extract of T. occidentalis, artesunate and the combination gave 72.17±4.07%, 70.43± 4.27% and 85.43±3.65% reduction in parasitaemia after 48hours respectively. A significant enhancement of the PCV was obtained with the coadministration of artesunate and aqueous extract (p< 0.01). Similar trends were also observed with heamatological parameters at 72hours of administration.ConclusionThis study revealed a synergistic effect of the co-administration on parasite clearance rate of P. berghei infection in mice, with a significant enhancement of haematological parameters within 48 hours of administration. This indicates a rapid rate of recovery from plasmodial infections with the co-administration. |
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