Phototherapy and risk of childhood cancer: A systematic review and meta-analysis |
| |
| Affiliation: | 1. Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran;2. Department of Public Health, Sirjan School of Medical Sciences, Sirjan, Iran;1. Princess Elizabeth Hospital, Neonatal Unit, Guernsey;2. The Townsville Hospital, Neonatal Unit, Townsville, Queensland, Australia;3. James Cook University, Townsville, Queensland, Australia;1. School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran;2. Nursing and Midwifery Care Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;3. Department of Pediatric Nursing, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran;4. Eye Research Center, Department of Ophthalmology, Mashhad University of Medical Sciences, Mashhad, Iran;5. Department of Pediatric Nursing, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran;1. Ankara City Hospital Child Health and Diseases - Division Neonatolojy, Ankara, Turkey;2. Ankara City Hospital Child Health and Diseases - Division Of Pediatric Surgery, Ankara, Turkey;3. SBU Ankara City Hospital Child Health and Diseases, Division of Pediatric Hematology, Turkey;1. Institute of General Practice and Public Health, Provincial College for Health Professions Claudiana, Via Lorenz-Böhler 13, 39100 Bolzano, Italy;2. Free University of Bozen/Bolzano, Piazza Università, 1, 39100 Bolzano, Italy;1. Lancashire Teaching Hospitals NHS Foundation Trust, United Kingdom;2. Newcastle University, United Kingdom;3. City, University of London, United Kingdom |
| |
| Abstract: | ObjectiveThis study aims to conduct a systematic review and meta-analysis of the scientific studies on the associations between phototherapy and risk of childhood cancer.MethodsElectronic databases including PubMed, Scopus, and Web of Science were searched until March 28, 2020. In general, 11 studies were included in the meta-analyses. Subgroup analyses were performed on the types of cancers and children's age, and the sensitivity analysis was done to search for heterogeneity sources.ResultsThe findings of the meta-analysis show that phototherapy was significantly associated with an increased risk of all types of cancers (RR = 1.28; 95% CI (1.08, 1.51)).ConclusionThis systematic review and meta-analyses indicated that neonatal phototherapy might be a possible risk factor for childhood cancer in general, and leukemia in particular. However, as the role of confounding factors were not controlled in many studies, future large cohorts are necessary in this regard. The findings of this study underscore the importance of greater adherence to scientific guidelines for thresholds of bilirubin for minimizing unnecessary exposure to phototherapy. |
| |
| Keywords: | Phototherapy Neoplasms Child meta-Analysis Systematic review |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
