Intra-familial transmission of Streptococcus dysgalactiae subsp. equisimilis (SDSE): A first case report and review of the literature |
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| Affiliation: | 1. Clinical Pathology and Laboratory Medicine, Anatomic Pathology, Saitama Cooperative Hospital, Saitama, Japan;2. Department of Pathology, National Institute of Infectious Diseases, Toyama, Shinjuku, Tokyo, Japan;3. Internal Medicine, Saitama Cooperative Hospital, Saitama, Japan;4. Clinical Pathology and Laboratory Medicine, Saitama Cooperative Hospital, Saitama, Japan;5. Pathogenic Microbe Laboratory, Research Institute, National Center for Global Health and Medicine, Toyama, Shinjuku, Tokyo, Japan;1. Division of General Pediatrics, Department of Pediatrics, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Japan;2. Division of Pediatric Infectious Diseases, Department of Pediatrics, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Japan;3. Department of Pediatrics, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Japan;4. Department of Otorhinolaryngology, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Japan;1. Department of Pharmacy, Fukuoka University Chikushi Hospital, 1-1-1 Zokumyoin, Chikushino-city, Fukuoka, 818-8502, Japan;2. Department of Respiratory Medicine, Fukuoka University Chikushi Hospital, 1-1-1 Zokumyoin, Chikushino-city, Fukuoka, 818-8502, Japan;3. Department of Clinical Laboratory, Fukuoka University Chikushi Hospital, 1-1-1 Zokumyoin, Chikushino-city, Fukuoka, 818-8502, Japan;4. Department of Infection Control, Fukuoka University Chikushi Hospital, 1-1-1 Zokumyoin, Chikushino-city, Fukuoka, 818-8502, Japan;5. Department of Pharmacy, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan;1. Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8431, Japan;2. Department of Pediatrics, San-Ikukai Hospital, 3-20-2 Taihei, Sumida-ku, Tokyo, 130-0012, Japan;3. Department of Pediatrics, Juntendo University Nerima Hospital, 3-1-10 Takanodai, Nerima-ku, Tokyo, 177-8521, Japan;4. Department of Pediatrics, Tokyo Rinkai Hospital, 1-4-2 Rinkai-cho, Edogawa-ku, Tokyo, 134-0086, Japan;5. Department of Pediatrics, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8431, Japan;6. Department of Pediatrics, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu-city, Chiba, 279-0021, Japan;1. Department of Infectious Diseases, Kagawa Prefectural Central Hospital 1-2-1 Asahi-machi, Takamatsu, Kagawa, 760-8557, Japan;2. Departments of General and Gastroenterological Surgery, Kagawa Prefectural Central Hospital 1-2-1 Asahi-machi, Takamatsu, Kagawa, 760-8557, Japan;1. Department of General Internal Medicine and Infectious Diseases, National Hospital Organization, Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo, 152-8902, Japan;2. Department of Microbiology and Infectious Diseases, Faculty of Medicine, Toho University, 5-21-16, Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan |
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| Abstract: | BackgroundConcern about Streptococcus dysgalactiae infections has been increasing worldwide, and many cases of invasive infections have been reported. Streptococcus dysgalactiae has two main subspecies: S. dysgalactiae subsp. equisimilis (SDSE) and S. dysgalactiae subsp. dysgalactiae (SDSD). The epidemiology of invasive SDSE infections is not well understood, and the exact numbers of human SDSE infections are not known because standard laboratories are not able to identify Lancefield group C streptococci (GCS) or group G streptococci (GGS) to the species level. SDSE is often present in skin lesions, and sites of SDSE colonization and focal SDSE infections serve as the principal reservoirs for the transmission of skin and soft-tissue infections. Although the person-to-person transmission of S. pyogenes infections has been reported, the intra-familial transmission of SDSE has not been reported.Case presentationWe report two cases of cellulitis with bacteremia in a family. A 72-year-old female with cellulitis in her right lower extremity was hospitalized, and a 104-year-old male relative was hospitalized with cellulitis 2 days later. Two strains of Streptococcus dysgalactiae subsp. equisimilis were isolated from the blood of the patients. Single nucleotide polymorphism analysis of the bacterial genomes suggested that the two strains had the same origin. This is the first case report about the intra-familial transmission of Streptococcus dysgalactiae subsp. equisimilis.ConclusionsThis is the first case report about the intra-familial transmission of Streptococcus dysgalactiae subsp. equisimilis. |
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| Keywords: | Bacteremia Intra-familial transmission Whole-genome sequencing |
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