A review of physical activity in pancreatic ductal adenocarcinoma: Epidemiology,intervention, animal models,and clinical trials |
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| Affiliation: | 1. Division of Gastroenterology, Hepatology, and Nutrition, Division of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA;2. The Comprehensive Cancer Center–Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, Columbus, OH, USA;3. Department of Pediatrics Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;1. Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Mayo Clinic, Rochester, MN, USA;2. University of Texas Health Science Center, San Antonio, TX, USA;3. Division of Gastroenterology and Hepatology, University of Illinois Chicago, Chicago, IL, USA;4. Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH, USA;5. Johns Hopkins Medical Institute, Baltimore, MD, USA;6. Pancreato-Biliary Endoscopy and Endosonography Division, IRCCS San Raffaele Scientific Institute, Milan, Italy;7. Division of Gastroenterology, Hospitals of the University of Pennsylvania, Philadelphia, PA, USA;8. University of Iowa, Stead Family Department of Pediatrics, Iowa City, IA, USA;9. Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, USA;10. Fraternal Order of Eagles Diabetes Research Center, USA;1. University of Pittsburgh Medical Center, Pittsburgh, PA, USA;2. University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, PA, USA;3. Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University, Wexner Medical Center, Columbus, OH, USA;4. MedStar Washington Hospital Center, Washington, DC, USA;5. Asian Gastroenterology Institute, Hyderabad, India;6. Postgraduate Institute of Medical Education and Research, Chandigarh, India;7. Apollo Gleneagles Hospitals Kolkata, Kolkata, India;8. Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania;9. Georgetown University Hospital, Washington, DC, USA;10. Universidad Autónoma de Nueva León, Monterrey, Mexico;11. Division of Gastroenterology, John Hopkins Medical Institution, Baltimore, MD, USA;12. Hospital Nacional de Itauguá, Itaugua, Paraguay;13. Cleveland Clinic, Cleveland, OH, USA;14. University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, Romania;15. Eastern Maine Medical Center, Bangor, ME, USA;p. Hospital Nacional “Professor Alejandro Posadas”, Buenos Aires, Argentina;q. Department of Gastroenterology, “Carol Davila” University of Medicine and Pharmacy, University Emergency Hospital Bucharest, Bucharest, Romania;r. Department of Pancreato-Biliary Endoscopy and Endosonography, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy;s. Department of Gastroenterology, Division of Gastroenterology, Indiana University School of Medicine, Indianapolis, IN, USA;t. Department of Medicine, Attikon University General Hospital, Athens, Greece;u. Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán-Universidad?Autónoma de Mexico, Mexico City, Mexico;v. Division of Gastroenterology, West Virginia University, Morgantown, WV, USA;w. Hospital General de Argudos “Dr. Cosme Argerich”, Buenos Aires, Argentina;x. Hospital General Universitario de Alicante, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL - Fundación FISABIO), Alicante, Spain;y. Medical University of South Carolina, Charleston, SC, USA;z. Kaiser Permanente, Los Angeles, CA, USA;11. Division of Gastroenterology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA;12. Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;13. Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, Ohio, USA;1. Department of Internal Medicine, Inje University College of Medicine, Haeundae Paik Hospital, South Korea;2. Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea;1. Division of Gastroenterology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA;2. Pancreatitis Center, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA;3. William H. Welch Medical Library, Johns Hopkins University, Baltimore, MD, USA;4. Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;5. Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH, USA;6. Division of Gastroenterology and Hepatology, Indiana University Medical Center, Indiana, USA;7. Centre for Pancreatic Diseases and Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark;8. Department of Clinical Medicine, Aalborg University Hospital, Aalborg, Denmark;1. Division of GI Surgery, GI Oncology, Minimal Access and Bariatric Surgery, Institute of Digestive and Hepatobiliary Sciences, Medanta - the Medicity, Sector 38, Gurugram, Haryana, 122001, India;2. Division of Surgery & Perioperative Medicine, Flinders Medical Center, Bedford Park, Adelaide, South Australia, Australia |
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| Abstract: | Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest types of cancer, and the increasing incidence of PDAC may be related to the prevalence of obesity. Physical activity (PA), a method known to mitigate obesity by increasing total energy expenditure, also modifies multiple cellular pathways associated with cancer hallmarks. Epidemiologic evidence has shown that PA can lower the risk of developing a variety of cancers, reduce some of the detrimental side effects of treatments, and improve patient's quality of life during cancer treatment. However, little is known about the pathways underlying the correlations observed between PA interventions and PDAC. Moreover, there is no standard dose of PA intervention that is ideal for PDAC prevention or as an adjuvant of cancer treatments. In this review, we summarize relevant literature showing how PDAC patients can benefit from PA, the potential of PA as an adjuvant treatment for PDAC, the studies using preclinical models of PDAC to study PA, and the clinical trials to date assessing the effects of PA in PDAC. |
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| Keywords: | Physical activity Exercise Pancreatic ductal adenocarcinoma Pancreatic cancer Translational research |
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