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Kinase signaling as a drug target modality for regulation of vascular hyperpermeability: A case for ARDS therapy development |
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| Affiliation: | 1. Akttyva Therapeutics, Inc., Mansfield, MA, USA;2. The George Washington University School of Medicine and Health Sciences, Washington, DC, USA;3. Université de Paris, Inserm UMR 1141, NeuroDiderot, Robert-Debré Hospital, 75019 Paris, France;4. Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA |
| Abstract: | |
| Keywords: | Vascular leak ARDS Drug discovery MK2 pathway Druggable pocket MAPK" },{" #name" :" keyword" ," $" :{" id" :" k65885" }," $$" :[{" #name" :" text" ," _" :" Mitogen-activated protein kinase MK2" },{" #name" :" keyword" ," $" :{" id" :" k3969" }," $$" :[{" #name" :" text" ," _" :" MAP kinase-activated protein kinase 2 HSP27" },{" #name" :" keyword" ," $" :{" id" :" k6798" }," $$" :[{" #name" :" text" ," _" :" Heat shock protein 27 ARDS" },{" #name" :" keyword" ," $" :{" id" :" k3788" }," $$" :[{" #name" :" text" ," _" :" Acute Respiratory Distress Syndrome |
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