Atopic Dermatitis and Celiac Disease: A Cross-Sectional Study of 116,816 Patients |
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Authors: | Shalom Guy Kridin Khalaf Raviv Keren-Or Freud Tamar Comaneshter Doron Friedland Rivka Cohen Arnon D. Ben-Amitai Dan |
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Affiliation: | 1.Clalit Health Services, Tel Aviv, Israel ;2.Division of Community Health, Faculty of Health Sciences, Siaal Research Center for Family Medicine and Primary Care, Ben Gurion University of the Negev, Beer-Sheva, Israel ;3.Department of Dermatology, Rambam Health Care Campus, P.O. Box 9602, Haifa, 31096, Israel ;4.Pediatric Dermatology Unit, Schneider Children’s Medical Center of Israel, Petach Tikva, Israel ;5.Chief Physician’s Office, Clalit Health Services, Tel Aviv, Israel ;6.Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel ; |
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Abstract: | Background Both atopic dermatitis and celiac disease are often accompanied by other immune-mediated disorders. ObjectiveThe objective of this study was to evaluate the potential association between atopic dermatitis and celiac disease in a broad community-based population. MethodsA cross-sectional observational design was used. Demographic and clinical data were collected for patients enrolled in a large health management organization who were diagnosed with atopic dermatitis by a dermatologist in 2002–17. The presence of celiac disease/celiac disease-related morbidities was recorded for the whole group, for adults (age > 18 years), and for adults with moderate-to-severe atopic dermatitis. Findings were compared with a matched control group without atopic dermatitis. ResultsThe study group included 116,816 patients of whom 45,157 were adults; 1909 adult patients had moderate-to-severe atopic dermatitis. Compared to the respective control subjects, the prevalence rate of celiac disease in the whole group was 0.6% vs. 0.4%; in the adults, 0.6% vs. 0.3%; and in the adults with moderate-to-severe atopic dermatitis, 0.8% vs. 0.3% (p < 0.001 for all). On multivariate analysis, atopic dermatitis was associated with a significantly higher prevalence of celiac disease (odds ratio = 1.609, 95% confidence interval 1.42–1.82, p < 0.001) in the entire study population and each subgroup. ConclusionsWe observed a significant association between atopic dermatitis and celiac disease. This association emphasizes the need for timely screening of gastrointestinal morbidities in individuals with atopic dermatitis to prevent long-term complications. |
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