| 泛素-蛋白酶体系统在非小细胞肺癌中作用机制的研究进展 |
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| 引用本文： | 王玉秀,闵凌峰.泛素-蛋白酶体系统在非小细胞肺癌中作用机制的研究进展[J].国际呼吸杂志,2020(4):297-301. |
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| 作者姓名： | 王玉秀 闵凌峰 |
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| 作者单位： | 江苏省苏北人民医院 |
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| 基金项目： | 国家自然科学基金(81302016);江苏省"六大人才高峰计划"(2015-WSN-106)。 |
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| 摘 要： | 泛素-蛋白酶体系统(UPS)是一个复杂的控制系统,负责降解80%~90%的蛋白质,是调节细胞功能和维持蛋白质同源性的关键。研究显示其在多种肿瘤发生、发展中有重要的作用,因此,近年来UPS的成分作为肺癌诊断以及治疗的潜在靶点引起了广泛的关注。本综述将对非小细胞肺癌中的UPS和UPS在非小细胞肺癌发生、发展中潜在的作用机制的研究现状作一综述。
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| 关 键 词： | 癌 非小细胞肺 泛素-蛋白酶体系统 作用机制 |
The potential mechanism of ubiquitin-proteasome system in non-small cell lung cancer |
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| Wang Yuxiu,Min Lingfeng.The potential mechanism of ubiquitin-proteasome system in non-small cell lung cancer[J].International Journal of Respiration,2020(4):297-301. |
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| Authors: | Wang Yuxiu Min Lingfeng |
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| Institution: | (Departmentof Respiratory Medicine,Northern Jiangsu People′s Hospital,Clinical Medical College of Yangzhou University,Yangzhou 225001,China) |
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| Abstract: | The ubiquitin-proteinasome system(UPS)is a complex control system responsible for the degradation of 80%-90%of proteins and is the key to regulating cellular function and maintaining protein homology.Studies have shown that it plays an important role in the development of a variety of tumors.Therefore,the component of UPS has attracted extensive attention as a potential target for the diagnosis and treatment of lung cancer in recent years.This article reviews the research status of UPS in non-small cell lung cancer and its potential mechanism in the development of non-small cell lung cancer. |
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| Keywords: | Carcinoma non-small-cell lung Ubquitin-proteinasome system Mechanism |
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