重视表观遗传修饰在视网膜血管性疾病中的调控作用

表观遗传学已成为生物医学领域的研究热点,疾病的发生不仅与遗传因素有关,而且还受到环境因素的影响。老年性黄斑变性、糖尿病视网膜病变等视网膜血管性疾病是一类以视网膜血管病变为核心病理改变的不可逆致盲性眼病,是多种环境因素和基因相互作用的结果。表观遗传学的调控方式主要包括DNA甲基化、组蛋白修饰和非编码RNA调控。表观遗传机制介导环境因素,参与视网膜血管病变相关基因的调控,影响疾病最终的发生发展。因此,眼科医生应重视表观遗传在视网膜血管性疾病中的作用,追踪表观遗传学方法在视网膜血管性疾病治疗中取得的进展,关注表观遗传学的应用前景。寻找这些疾病的表观调控因子,不仅可以加深对这些疾病发生机制的认识,同时还能为这些疾病的诊断和治疗提供新的思路。

Focusing on the regulation of epigenetic modification on retinal vascular disease

Epigenetics has been very hot in the research of biomedicine.In addition to genetic factors,the occurrence of a disease is also influenced by environmental factors.Retinal vascular diseases are a type of irreversible blind eye disease,such as age-related macular degeneration and diabetic retinopathy.The retinal vessel changes are the major features of retinal vascular diseases,which are the result of interaction of multiple environmental factors and genes.Epigenetic modification mainly includes DNA methylation,histone modification,and non-coding RNA regulation.Epigenetic mechanisms mediate the effects of environmental factors on genes related to retinal vascular diseases,and affect the eventual development of the diseases.Therefore,ophthalmologists should keep eyes close on the role of epigenetics in retinal vascular diseases,track the progress of epigenetic methods in the treatment of retinal vascular diseases,and pay attention to the application prospects of epigenetics.Finding the epigenetic regulators of these diseases can not only deepen the understanding of the pathological mechanism of these diseases,but also provide new ideas for the diagnosis and treatment of these diseases.