Organoids in modelling infectious diseases |
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| Affiliation: | 1. World-Class Research Center ‘Digital Biodesign and Personalized Healthcare’, Sechenov First Moscow State Medical University, Moscow, Russia;2. Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, Moscow, Russia;3. Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Academic Center for Education, Culture and Research (ACECR), Tehran, Iran;4. FSBSI ‘Institute of General Pathology and Pathophysiology’, Moscow, Russia;5. Chemistry Department, Lomonosov Moscow State University, Moscow, Russia;6. Department of Polymers and Composites, NN Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Moscow, Russia |
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| Abstract: | Approaches based on animal and two-dimensional (2D) cell culture models cannot ensure reliable results in modeling novel pathogens or in drug testing in the short term; therefore, there is rising interest in platforms such as organoids. To develop a toolbox that can be used successfully to overcome current issues in modeling various infections, it is essential to provide a framework of recent achievements in applying organoids. Organoids have been used to study viruses, bacteria, and protists that cause, for example, respiratory, gastrointestinal, and liver diseases. Their future as models of infection will be associated with improvements in system complexity, including abilities to model tissue structure, a dynamic microenvironment, and coinfection.Teaser.Organoids are a flexible tool for modelling viral, bacterial and protist infections. They can provide fast and reliable information on the biology of pathogens and in drug screening, and thus have become essential in combatting emerging infectious diseases. |
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| Keywords: | Organoids Infectious diseases Infection Drug screening Viruses Bacteria Protists ASC" },{" #name" :" keyword" ," $" :{" id" :" k0045" }," $$" :[{" #name" :" text" ," _" :" adult stem cell ECM" },{" #name" :" keyword" ," $" :{" id" :" k0055" }," $$" :[{" #name" :" text" ," _" :" extracellular matrix HAND" },{" #name" :" keyword" ," $" :{" id" :" k0065" }," $$" :[{" #name" :" text" ," _" :" HIV-1 associated neurocognitive disorder HBV" },{" #name" :" keyword" ," $" :{" id" :" k0075" }," $$" :[{" #name" :" text" ," _" :" hepatitis B virus HCMV" },{" #name" :" keyword" ," $" :{" id" :" k0085" }," $$" :[{" #name" :" text" ," _" :" human cytomegalovirus HCV" },{" #name" :" keyword" ," $" :{" id" :" k0095" }," $$" :[{" #name" :" text" ," _" :" hepatitis C virus HIV" },{" #name" :" keyword" ," $" :{" id" :" k0105" }," $$" :[{" #name" :" text" ," _" :" human immunodeficiency virus HPIV3" },{" #name" :" keyword" ," $" :{" id" :" k0115" }," $$" :[{" #name" :" text" ," _" :" human parainfluenza virus 3 HSV-1" },{" #name" :" keyword" ," $" :{" id" :" k0125" }," $$" :[{" #name" :" text" ," _" :" herpes simplex virus 1 iPSC" },{" #name" :" keyword" ," $" :{" id" :" k0135" }," $$" :[{" #name" :" text" ," _" :" induced pluripotent stem cell RSV" },{" #name" :" keyword" ," $" :{" id" :" k0145" }," $$" :[{" #name" :" text" ," _" :" respiratory syncytial virus SARS-CoV-2" },{" #name" :" keyword" ," $" :{" id" :" k0155" }," $$" :[{" #name" :" text" ," _" :" severe acute respiratory syndrome coronavirus 2 ZIKV" },{" #name" :" keyword" ," $" :{" id" :" k0165" }," $$" :[{" #name" :" text" ," _" :" Zika virus |
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