Prevalence and prognosis of increased pancreatic enzymes in patients with COVID-19: A systematic review and meta-analysis |
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| Institution: | 1. Department of Pancreatic Surgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China;2. Department of Medicine, University of Maryland Medical Center Midtown Campus, Baltimore, MD, USA;3. Health Sciences and Human Services Library, University of Maryland, 601 W Lombard St, Baltimore, MD, 21201, USA;4. Department of Medicine, SUNY Downstate Health and Science University, Brooklyn, NY, 11203, USA;5. Internal Medicine, AMITA Health Saint Joseph Hospital Chicago, Chicago, IL, USA;6. HPB and Transplant Unit, Freeman Hospital, Newcastle upon Tyne, UK;7. Surgical and Translational Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland, 1142, New Zealand |
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| Abstract: | IntroductionThe prevalence of increased pancreatic enzymes (elevated serum amylase and/or lipase) and its relationship to clinical outcomes in patients with coronavirus disease 2019 (COVID-19) infection is not known.MethodsA systematic review and meta-analysis of relevant studies reporting prevalence and impact of increased pancreatic enzymes (defined as an elevation in amylase and/or lipase levels above the upper limit of normal ULN] value) in COVID-19 was undertaken.ResultsA total of 36,496 patients from 21 studies were included for this meta-analysis. The overall prevalence and mortality for increased pancreatic enzymes (>ULN) in COVID-19 were 25.4% (95% CI, 15.8%–36.2%) and 34.6% (95% CI, 25.5%–44.4%), respectively. The overall prevalence and mortality for increased pancreatic enzymes (>3 × ULN) were 6.1% (95% CI, 3.6%–9.2%) and 39.2% (95% CI, 18.7%–61.6%), respectively. Patients with increased pancreatic enzymes, including elevated serum lipase or amylase of either type, had worse clinical outcomes, including need for ICU admission, mechanical ventilation and mortality.DiscussionIncreased pancreatic enzymes is frequent and may exacerbate the consequences of COVID-19 infection. |
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| Keywords: | Amylase Lipase COVID-19 Prevalence Prognosis |
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