Advancement of cell-penetrating peptides in combating triple-negative breast cancer |
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Affiliation: | 1. Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110 062, India;2. Department of Pharmaceutics, College of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia;3. Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Minia University, Minia 61519, Egypt;4. Department of Pharmaceutics, Delhi Pharmaceutical Sciences and Research University, New Delhi 110 017, India;5. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;6. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran |
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Abstract: | Extensive research efforts have been made and are still ongoing in the search for an ideal anti-cancer therapy. Almost all chemotherapeutics require a carrier or vehicle, a drug delivery system that can transport the drug specifically to the targeted cancer cells, sparing normal cells. Cell-penetrating peptides (CPPs) provide an effective and efficient pathway for the intra-cellular transportation of various bioactive molecules in several biomedical therapies. They are now well-recognized as facilitators of intracellular cargo delivery and have excellent potential for targeted anti-cancer therapy. In this review, we explain CPPs, recent progress in the development of new CPPs, and their utilization to transport cargoes such as imaging agents, chemotherapeutics, and short-interfering RNAs (siRNA) into tumor cells, contributing to the advancement of novel tumor-specific delivery systems. |
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Keywords: | Cell-penetrating peptides Triple-negative breast cancer Chemotherapy Drug delivery Nanotechnology Nanocarriers Akt" },{" #name" :" keyword" ," $" :{" id" :" k0040" }," $$" :[{" #name" :" text" ," _" :" Protein kinase B B1R" },{" #name" :" keyword" ," $" :{" id" :" k0050" }," $$" :[{" #name" :" text" ," _" :" Kinin B1 BBB" },{" #name" :" keyword" ," $" :{" id" :" k0060" }," $$" :[{" #name" :" text" ," _" :" Blood–brain barrier BC" },{" #name" :" keyword" ," $" :{" id" :" k0070" }," $$" :[{" #name" :" text" ," _" :" Breast cancer BR1A" },{" #name" :" keyword" ," $" :{" id" :" k0080" }," $$" :[{" #name" :" text" ," _" :" B1R-antagonist CI" },{" #name" :" keyword" ," $" :{" id" :" k0090" }," $$" :[{" #name" :" text" ," _" :" Combination index CP-B1RA" },{" #name" :" keyword" ," $" :{" id" :" k0100" }," $$" :[{" #name" :" text" ," _" :" Cell-penetrating B1RA CPP" },{" #name" :" keyword" ," $" :{" id" :" k0110" }," $$" :[{" #name" :" text" ," _" :" Cell-penetrating peptide CPPP" 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:" Near-infrared fluorescence imaging NP" },{" #name" :" keyword" ," $" :{" id" :" k0290" }," $$" :[{" #name" :" text" ," _" :" Nanoparticle PI3K" },{" #name" :" keyword" ," $" :{" id" :" k0300" }," $$" :[{" #name" :" text" ," _" :" Phosphatidylinositol-3-kinase PCNA" },{" #name" :" keyword" ," $" :{" id" :" k0310" }," $$" :[{" #name" :" text" ," _" :" Proliferation cell nuclear antigen PDC" },{" #name" :" keyword" ," $" :{" id" :" k0320" }," $$" :[{" #name" :" text" ," _" :" Drug–peptide conjugate PEG" },{" #name" :" keyword" ," $" :{" id" :" k0330" }," $$" :[{" #name" :" text" ," _" :" Polyethylene glycol PEI" },{" #name" :" keyword" ," $" :{" id" :" k0340" }," $$" :[{" #name" :" text" ," _" :" Polyethyleneimine PET" },{" #name" :" keyword" ," $" :{" id" :" k0350" }," $$" :[{" #name" :" text" ," _" :" Positron emission tomography PR" },{" #name" :" keyword" ," $" :{" id" :" k0360" }," $$" :[{" #name" :" text" ," _" :" Progesterone receptor PTX" },{" #name" :" keyword" ," $" :{" id" :" k0370" }," $$" :[{" #name" :" text" ," _" :" Paclitaxel RICTOR" },{" #name" :" keyword" ," $" :{" id" :" k0380" }," $$" :[{" #name" :" text" ," _" :" Rapamycin-insensitive companion of mTOR siEGFR" },{" #name" :" keyword" ," $" :{" id" :" k0390" }," $$" :[{" #name" :" text" ," _" :" EGFR-targeted siRNA siRNA" },{" #name" :" keyword" ," $" :{" id" :" k0400" }," $$" :[{" #name" :" text" ," _" :" short interfering RNA tFNA" },{" #name" :" keyword" ," $" :{" id" :" k0410" }," $$" :[{" #name" :" text" ," _" :" Tetrahedral framework nucleic acid TKI" },{" #name" :" keyword" ," $" :{" id" :" k0420" }," $$" :[{" #name" :" text" ," _" :" Tyrosine kinase inhibitor TNBC" },{" #name" :" keyword" ," $" :{" id" :" k0430" }," $$" :[{" #name" :" text" ," _" :" Triple-negative breast cancer TTP" },{" #name" :" keyword" ," $" :{" id" :" k0440" }," $$" :[{" #name" :" text" ," _" :" Tumor-penetrating peptide UI" },{" #name" :" keyword" ," $" :{" id" :" k0450" }," $$" :[{" #name" :" text" ," _" :" Ultrasonic irradiation UTMD" },{" #name" :" keyword" ," $" :{" id" :" k0460" }," $$" :[{" #name" :" text" ," _" :" Ultrasound-targeted microbubble destruction wtp53" },{" #name" :" keyword" ," $" :{" id" :" k0470" }," $$" :[{" #name" :" text" ," _" :" Wild-type p53 |
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