Drug-induced QT Prolongation Atlas (DIQTA) for enhancing cardiotoxicity management |
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Institution: | 1. College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, China;2. Medical Big Data Center, Sichuan University, Chengdu, Sichuan 610064, China |
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Abstract: | Drug-induced prolongation of the QT interval is common in a variety of pharmaceutical treatments and can lead to serious clinical outcomes. Although substantial efforts have been made to prevent drug-induced QT interval prolongation, the lack of a centralized data source remains the main obstacle to further study of the underlying mechanism and the development of effective prediction strategies. To fill this gap, we propose a schema for stratifying the risk of marketed QT prolonging drugs based on US Food and Drug Administration (FDA)-approved drug labeling and developed a Drug-Induced QT Prolongation Atlas (DIQTA). Potential application of DIQTA was shown by precision dosing in off-label use and therapeutic strategy optimization, as well as the facilitation of artificial intelligence (AI)-based modeling in predictive toxicity. |
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Keywords: | Drug-induced prolongation of the QT interval Torsades de pointes Cardiotoxicity Drug safety Adverse drug reaction |
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