A GLC method for estimation of chlorophenoxyisobutyric acid in plasma. Pharmacokinetics of a single oral dose of clofibrate in man |
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| Authors: | G. Houin J. J. Thébault Ph d'Athis J. -P. tillement J. -L. Beaumont |
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| Affiliation: | (1) Département de Pharmacologie, Faculté de Médecine de Créteil, Unité de Recherches sur l'Athérosclérose de l'Inserm and Service de Médecine Interne de L'Hopital Henri Mondor, Créteil, France |
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| Abstract: | Summary A GLC method has been developed to measure chlorophenoxyisobutyric acid in plasma after benzol extraction and transformation to its methyl ester, using methyl laurate as the internal standard. Plasma free fatty acids did not interfere with the analysis, but it could not be employed in the presence of salicylates. The method has been employed to study the pharmacokinetics of chlorophenoxyisobutyric acid in man after oral ingestion of a single dose of clofibrate. |
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| Keywords: | clofibrate chlorophenoxyisobutyric acid plasma kinetics GLC analytical method |
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