Voxel-based analysis of diffusion tensor indices in the brain in patients with Parkinson's disease |
| |
Authors: | Kaiyuan Zhang Chunshui Yu Yujin Zhang Chaozhe Zhu Kuncheng Li |
| |
Institution: | a Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, PR China b Key Laboratory of Neurodegenerative Diseases, Capital Medical University, Ministry of Education, PR China c State Key Laboratory of Cognitive Neurosciences and Learning, Beijing Normal University, Beijing 100875, PR China d Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, PR China |
| |
Abstract: | PurposeTo investigate the abnormal diffusion in cerebral white matter and its relationship with the olfactory dysfunction in patients with Parkinson's disease (PD) through diffusion tensor imaging (DTI).Materials and methodsDiffusion tensor imaging of the cerebrum was performed in 25 patients with Parkinson's disease and 25 control subjects matched for age and sex. Differences in fractional anisotropy (FA) and mean diffusivity (MD) between these two groups were studied by voxel-based analysis of the DTI data. Correlations between diffusion indices and the olfactory function in PD patients were evaluated using the multiple regression model after controlling for the duration of the disease, Unified Parkinson's Disease Rating Sale (UPDRS), and age.ResultsThe damaged white and gray matter showed decreased FA or increased MD, localized bilaterally in the cerebellar and orbitofrontal cortex. In addition, in PD patients there was a positive correlation between FA values in the white matter of the left cerebellum and the thresholds of olfactory identification (TOI) and a negative correlation between MD values in the white matter of right cerebellum and the TOI.ConclusionIn patients with PD, there was disruption in the cerebellar white matter which may play an important role in the olfactory dysfunction in patients with Parkinson's disease. |
| |
Keywords: | Parkinson's disease Diffusion tensor imaging Voxel-based analysis Cerebellum Olfactory dysfunction |
本文献已被 ScienceDirect 等数据库收录! |
|