Synthesis and development of poly(N-hydroxyethyl acrylamide)-ran-3-acrylamidophenylboronic acid polymer fluid for potential application in affinity sensing of glucose |
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Authors: | Li Siqi Davis Erin N Huang Xian Song Bing Peltzman Rebecca Sims David M Lin Qiao Wang Qian |
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Affiliation: | Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, USA. |
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Abstract: | BackgroundIn previous work, we described viscosity and permittivity microelectromechanical systems (MEMS) sensors for continuous glucose monitoring (CGM) using poly[acrylamide-ran-3-acrylamidophenylboronic acid (PAA-ran-PAAPBA). In order to enhance our MEMS device antifouling properties, a novel, more hydrophilic polymer-sensing fluid was developed.MethodTo optimize sensing performance, we synthesized biocompatible copolymers poly(N-hydroxyethyl acrylamide)-ran-3-acrylamidophenylboronic acid (PHEAA-ran-PAAPBA) and developed its sensing fluid for viscosity-based glucose sensing. Key factors such as polymer composition and molecular weight were investigated in order to optimize viscometric responses.ResultsCompared with PAA-ran-PAAPBA fluid of a similar binding moiety percentage, PHEAA-ran-PAAPBA showed comparable high binding specificity to glucose in a reversible manner and even better performance in glucose sensing in terms of glucose sensing range (27–468 mg/ml) and sensitivity (within 3% standard error of estimate). Preliminary experiment on a MEMS viscometer demonstrated that the polymer fluid was able to sense the glucose concentration.ConclusionsOur MEMS systems using PHEAA-ran-PAAPBA will possess enhanced implantable traits necessary to enable CGM in subcutaneous tissues. |
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Keywords: | antifouling boronic acid continuous glucose monitoring microelectromechanical systems poly(acrylamide-ran-3-acrylamidophenylboronic acid) poly(N-hydroxyethyl acrylamide)-ran-3-acrylamidophenylboronic acid) |
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