凋亡抑制蛋白XIAP在儿童急性白血病中的表达及其临床意义

目的探讨凋亡抑制蛋白XIAP在儿童急性白血病（AL）中的表达及其临床意义。方法54例AL患儿，其中初诊未治26例，治疗后完全缓解（CR）23例，复发5例。应用免疫组织化学方法检测其骨髓细胞XIAP蛋白表达。对照组为10例非恶性血液病且骨髓正常患儿。结果初诊未治AL患儿骨髓中XIAP蛋白表达水平高于缓解期（P〈0．05）和对照组（P〈0．05），和复发组相比差异无统计学意义（P〉0．05），且缓解期仍高于对照组（P〈0．05）；初诊未治AL患儿骨髓中XIAP蛋白水平在急性淋巴细胞白血病（ALL）和急性非淋巴细胞白血病（ANLL）组比较差异无统计学意义（P〉0．05）。结论XIAP蛋白在儿童AL患者中高表达，提示XIAP可能通过抑制肿瘤细胞的凋亡参与了儿童AL的发生、发展。

Expression and clinical significance of inhibitor of apoptosis protein XIAP in chiIdhood acute leukemia

Objective To investigate the expression and clinical significance of inhibitor of apoptosis protein XIAP in childhood acute leukemia(AL).Methotis The expression of XIAP protein was detected by immunohistochemical assay in 54 children with AL.including 26 newly diagnosed and untreated AL children.23 children in remission and 5 relapsed.The eontrol included 10 children with normal bone marrow.Results The level of XIAP proteins in the bone marrow of newly diagnosed AL children was higher than that in remission and normal controls(P＜0.05),compared with that in relapsed children,with no statistical difference(P＞0.05).The level of XIAP protein in remission was higher than that in normal controls(P＜0.05).The level of XIAP protein in ALL and ANLL in newly diagnosed AL children was compared. with no statistical difference(P＞0.05).Conclusion The higher expression of XIAP may contribute to the pathogenesis and the progress of the childhood AL.