| HOXA11和ER、PR在输卵管及异位妊娠输卵管黏膜上皮中的表达 |
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| 引用本文： | 裴 丹,唐 颖,邹忠文,白春侠,王莉芬. HOXA11和ER、PR在输卵管及异位妊娠输卵管黏膜上皮中的表达[J]. 大连医科大学学报, 2008, 30(2): 97-100 |
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| 作者姓名： | 裴 丹 唐 颖 邹忠文 白春侠 王莉芬 |
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| 作者单位： | 大连医科大学附属第二医院妇产科,辽宁,大连,116027;大连医科大学附属第二医院病理科,辽宁,大连,116027;辽宁医学院附属第一医院,辽宁,锦州,121000 |
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| 摘 要： | [目的]探讨HOXA11在异位妊娠输卵管中的作用，以及与ER、PR的关系。[方法]采用免疫组化方法检测34例正常输卵管和36例异位妊娠输卵管黏膜上皮中HOXA11和ER、PR的表达。[结果]HOXA11在异位妊娠输卵管黏膜上皮中表达最高，在正常增生期和分泌期输卵管黏膜上皮中表达明显下降（P〈0．05）；ER、PR在正常增生期和分泌期输卵管黏膜上皮中表达较高，在异位妊娠输卵管黏膜上皮中表达明显下降（P〈0．05）。[结论]HOXA11在输卵管黏膜上皮中表达增强和ER、PR表达下降可能与输卵管异位妊娠相关；在正常分泌期输卵管黏膜上皮中，HOXA11表达下调和ER、PR表达水平上调可能起着屏障作用，防止输卵管着床的发生。
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| 关 键 词： | HOXA11基因 ER PR 输卵管 异位妊娠 |
| 文章编号： | 1671-7295(2008)02-0097-04 |
| 修稿时间： | 2007-11-07 |
Expression of HOXA11 and ER,PR in human fallopian tube and ectopic pregnant fallopian tube |
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| PEI Dan,TANG Ying,ZOU Zhong-wen,BAI Chun-xia and WANG Li-fen. Expression of HOXA11 and ER,PR in human fallopian tube and ectopic pregnant fallopian tube[J]. Journal of Dalian Medical University, 2008, 30(2): 97-100 |
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| Authors: | PEI Dan TANG Ying ZOU Zhong-wen BAI Chun-xia WANG Li-fen |
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| Affiliation: | 1.Department of Obstetrics and Gynecology;the Second Affiliated Hospital of Dalian Medical University;Dalian 116027;China;2.Department of Pathology;3.The First Affiliated Hospital of Liaoning Medical University;Jinzhou 121000;China |
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| Abstract: | [Objective] To investigate the expression of HOXA11,estrogen receptor(ER) and progesterone receptor(PR) in human fallopian tube and ectopic pregnant fallopian.[Methods] The expression of HOXA11 and steroid receptor proteins were detected in 36 samples ectopic pregnant fallopian and 34 samples of normal oviduct by immunohistochenmistry.[Results] HOXA11 expression was noted in epithelial cells of ectopic pregnant fallopian tube,but the intensity of staining in normal oviduct was less.The expression level of E... |
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| Keywords: | HOXA11 gene estrogen receptor progesterone receptor fallopian tube ectopic pregnancy |
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