抗氧化剂治疗对腹膜透析患者微炎症状态的影响

目的 观察抗氧化剂治疗对腹膜透析患者微炎症状态的影响。方法选择我院透析中心的84例腹膜透析患者，测定不同透析处方治疗组（维生素E治疗组、普罗布考治疗组、对照组）治疗前后的超敏C反应蛋白（hs—CRP）、血浆白蛋白、血红蛋白、KT／V、残肾内生肌酐清除率等相关指标，并作比较分析。结果治疗前3组间各检测指标的差异均无统计学意义（P〉0．05）；治疗后普罗布考组hs—CRP水平[（4．47±221）mg／L]均显著低于维生素E组及对照组[（6．03±2．23）、（627±2．16）mg／L]（P〈0.01），各组间其他指标均无明显差异（均P〉0.05）。结论抗氧化剂普罗布考对微炎症状态的改善有着积极的作用，可以在一定程度上改善腹膜透析患者的预后。

Effect of antioxidants therapy on microinflammatory state in patients undergoing peritoneal dialysis

Objective To investigate the effect of antioxidants on microintlammatory state in patients undergoing peritoneal dialysis （PD）. Methods Eighty four patients who underwent peritoneal dialysis were divided into vitamin E Group, probucol Group and control group. The blood levels of hs-CRP, AIb, Hb, KT/V and Ccr were measured before and after the therapy. Results The hypersensitive CRP （hs-CRP） levels in probucol group were significantly decreased after therapy （P〈 0.01）; while there were no significant changes in vitamin E group （P〉 0.05）. Conclusion Probucol can improve the microinflammatory state in patients undergoing peritoneal dialysis and may improve the prognosis of patients.