| 白花前胡甲素对Ang II诱导的核转录因子c-Jun蛋白表达的影响 |
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| 引用本文： | 王颖,燕树勋,贾玲,田玲,涂欣,吕久省.白花前胡甲素对Ang II诱导的核转录因子c-Jun蛋白表达的影响[J].辽宁中医杂志,2008,35(2). |
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| 作者姓名： | 王颖 燕树勋 贾玲 田玲 涂欣 吕久省 |
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| 基金项目： | 湖北省科技厅重点科学技术项目，湖北省卫生厅医药卫生科研项目 |
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| 摘 要： | 目的:探讨白花前胡甲素(Pd-Ia)对Ang II诱导的核转录因子c-Jun蛋白表达水平的影响。方法:体外原代培养乳鼠心肌细胞;免疫细胞化学检测核转录因子c-Jun蛋白表达情况。结果:AngII(10-6mol/L)刺激心肌细胞2h后,细胞核内c-Jun蛋白表达显著增强,为对照组的2.8倍(P<0.01);白花前胡甲素对此有显著抑制作用(P<0.05)。结论:白花前胡甲素能够拮抗AngII诱导心肌细胞c-Jun蛋白表达上调。
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| 关 键 词： | 白花前胡甲素 血管紧张素 心肌细胞 c-Jun蛋白 |
Effect of Pd-Ia on Angiotensin II Induced c-Jun Protein Expression in Cardiomyocytes |
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| Abstract: | Objective: To study the effect of Pd-Ia on angiotensin II induced c-jun protein expression in cardiomyocytes.Methods: Neonatal rat cardiomyocytes were cultured in vitro.c-Jun protein expression was examined by immunocytochemistry.Results: After 2h,AngII stimulation resulted in 2.8-fold increased c-Jun protein expression in cardiomyocytes(P<0.01).Pd-Ia significantly inhibited AngII induced c-Jun protein expression.Conclusion: Pd-Ia could inhibit AngII induced c-Jun expression in cardiomyocytes. |
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| Keywords: | Pd-Ia angiotensin cardiomyocytes c-Jun protein |
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