| 尼莫地平缓释片的制备及体外释药特性的评价 |
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| 引用本文： | 管清香,林天慕,张恒弼.尼莫地平缓释片的制备及体外释药特性的评价[J].吉林大学学报(医学版),2002,28(2):141-143. |
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| 作者姓名： | 管清香 林天慕 张恒弼 |
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| 作者单位： | 1. 吉林大学药学院药剂教研室,吉林,长春,130021;2. 第四军医大学吉林军医学院药学教研室;3. 解放军第208医院药剂科 |
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| 摘 要： | 目的:制备高效、长效的尼莫地平缓释片.方法:正交设计法对片剂处方进行筛选与优化.将尼莫地平固体分散体与羟丙甲基纤维素等混合,干法直接压制缓释片,测定其释药特性.结果:缓释片体外释药符合Higuchi方程(r=0.990 8)和一级动力学(r=0.994 0).处方4的t50=2.39 h且可持续释药达10 h以上.HPMC、乳糖、聚乙二醇6000及甲基纤维素水平的变化对释药速率均有显著影响(P＜0.01).结论:制备的缓释片具有高效、长效的特点.
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| 关 键 词： | 尼莫地平 固体分散体 缓释片 体外释放度 |
| 文章编号： | 1671-587X(2002)02-0141-03 |
| 修稿时间： | 2001年5月18日 |
Formulation and evaluation of sustained release tablets of nimodipine |
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| GUAN Qing xiang ,LIN Tian mu ,ZHANG Hong bi.Formulation and evaluation of sustained release tablets of nimodipine[J].Journal of Jilin University: Med Ed,2002,28(2):141-143. |
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| Authors: | GUAN Qing xiang LIN Tian mu ZHANG Hong bi |
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| Institution: | GUAN Qing xiang 1,LIN Tian mu 2,ZHANG Hong bi 3 |
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| Abstract: | Objective: To prepare effective and long termed action nimodipine sustained release tablets. Methods: The orthogonal test was employed in the formulations. Nimodipine solid dispersion, hydroxypropylmethylcellulose (HPMC) and other excipients were mixed to prepare tablets by power compression. An optimum formulation was screened by comparing release characteristics. Results: The dissolution behavior in vitro of the nimodipine sustained release tablets followed Higuchi kinetic and first order kinetic equation. Its t 50 was 2.39 h and the release of drug was retarded over 10 h. Analysis of variance demonstrated variations of the amount of HPMC, lactose, methylcellulose and PEG6000 had significant effects on release rates ( P <0. 01). Conclusion: The effective and sustained release tablets with long term action have been prepared. |
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| Keywords: | nimodipine solid dispersion sustained release tablet dissolution rate in vitro |
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