肿瘤患者红细胞免疫功能和sIL-2R检测的意义

目的 :探讨肿瘤患者红细胞 (RBC)免疫功能与白细胞介素 2受体 (sIL 2R)变化的意义。方法 :采用免疫黏附酵母菌花环法 ,检测 116例恶性肿瘤患者的RBCC3b受体花环率 (RBC C3bRR)、RBC免疫复合物花环率 (RBC ICR) ,用双抗体夹心ELISA法测患者血清sIL 2R ,并与 5 0例健康对照相比较。结果 :消化道肿瘤组、胸腺瘤组RBC C3bRR与正常对照组相比较 ,显著降低 ,差异有极显著性 (P <0 0 1) ;肺癌组、淋巴瘤组RBC C3bRR与对照组相比 ,显著降低 ,差异有显著性 (P <0 0 5 ) ;而各肿瘤组RBC ICR与正常对照组相比 ,显著增多 ,差异有极显著性 (P <0 0 1)。各肿瘤组间RBC C3bRR、RBC ICR差异均无显著性 (P >0 0 5 )。各肿瘤组与正常对照组相比 ,sIL 2R水平明显增高 (P <0 0 1) ,各肿瘤组间差异无显著性 (P >0 0 5 )。结论 :测定RBC免疫功能和sIL 2R ,可了解肿瘤患者的免疫状态 ,在一定程度上对疾病的严重程度、肿瘤分期、疗效及预后作出正确的评估

Significance of Erythrocyte Immune Functions and Soluble Interleukin-2 Receptor in The Malignant Tumor Patients

Objective To research the significance of Erythrocyte immune functions (RBC C 3bRR,RBC ICR) and soluble interleukin 2 receptor (sIL 2R) in the patients suffered from the malignant tumor.Methods RBC C 3bRR and RBC ICR were detected with the immune adhesiveness method and sIL 2R was detected by EILSA in 116 patients suffered from the malignant tumor and 50 healthy adults.Results The results showed that RBC C 3bRR of patients in thymoma and tumors of the alimentary tract were significantly lower than those in the control group ( P <0 01).Lung cancer and lymphoma were lower than those in the control group ( P <0 05);But RBC ICR of patients were significantly higher than those in the control group ( P <0 01).The values of sIL 2R in each cancer group were higher than those in the control group ( P <0 01).Conclusions It suggested that measurement of erythrocyte immune functions and soluble interleukin 2 receptor might be useful in diagnosis and prognosis.