孕妇妊娠期甲状腺激素水平变化及与TPOAb的相关性研究

目的：探讨孕妇妊娠期甲状腺激素水平变化及与抗甲状腺过氧化物酶抗体（TPOAb）的相关性。方法选取2012年11月至2014年5月来宁夏回族自治区石嘴山市妇幼保健院进行检查的150例孕妇作为研究对象，根据TPOAb对孕妇进行分组。比较两组孕妇的临床资料、血清甲状腺激素水平、妊娠结局和新生儿并发症的发生率。结果150例患者中，TPOAb阳性者44例，阴性106例。两组孕妇的年龄、孕周和BMI差异无统计学意义（P＞0．05）。妊娠早中期和晚期，两组孕妇的甲状腺激素水平差异有统计学意义（P＜0．05）；观察组（TPOAb阳性）孕妇妊娠前后的甲状腺激素水平差异有统计学意义（P＜0．05）。两组孕妇的不良妊娠结局和新生儿并发症的发生率差异有统计学意义（P＜0．05）。结论妊娠期的TPOAb对妊娠期亚临床甲状腺功能减退的诊断和妊娠结局的判断具有一定的意义。

The relevance between the level of thyroid hormone and TPOAb during gestation period

Objective To study the relevance between the level of thyroid hormone and anti‐thyroid peroxidase antibody (TPOAb) during gestation period .Methods From November 2011 to May 2014 ,150 gravidas were chosen as objectives ,and were divided into 2 groups according TPOAb .The clinical feature ,level of thyroid hormone ,pregnancy outcome ,and complication of neo‐phyte between 2 groups were compared .Results In 150 gravidas ,44 were positive in TPOAb and 106 were negative .The age ,ges‐tational weeks and BMI between two groups had no statistical difference(P>0 .05) .At the early and middle pregnancy as well as at the late pregnancy ,the level of thyroid hormone between two groups had statistical difference(P<0 .05);In study group ,the level of thyroid hormone of early and middle pregnancy and that of late pregnancy had statistical difference(P<0 .05) .The rate of unde‐sirable gestational outcome and that of neophyte complication between two groups had statistical difference(P<0 .05) .Conclusion During gestation period ,the TPOAb was significant for the diagnosis of the sub‐clinical hypothyroidism ,as well for prognosis of gravidas .