下丘脑-小脑神经通路在大鼠躯体-内脏反应整合中的作用

目的：探索 SD 大鼠下丘脑‐小脑神经通路在躯体‐内脏反应整合过程中发挥的作用。方法将120只 SD 大鼠随机分为6组；分别在大鼠小脑深部核团定点微量注射生理盐水（A 组），组胺 H1受体阻断剂 triprolidine（B 组），组胺 H1受体激动剂2‐PyEA（C 组），组胺 H2受体阻断剂 ranitidine（D 组），组胺 H2受体激动剂 dimaprit（E 组），以及神经递质组胺（F 组）。以 A 组为对照，观察下丘脑‐小脑组胺能神经纤维信号被阻断或强化后，大鼠躯体‐内脏反应整合能力的变化。结果与 A 组相比，B 组和C 组无明显效应，而 D 组大鼠躯体‐内脏反应整合被明显阻断，而 E 组和 F 组大鼠躯体‐内脏反应整合被明显强化。结论小脑组胺能传入纤维参与了机体躯体‐内脏反应整合的调控，并且是通过 H2受体途径发挥效应的。

The role of hypothalamocerebellar histaminergic projections in somatic-visceral integration of rats

Objective To research the role of hypothalamocerebellar histaminergic projections in somatic‐visceral integration of rats .Methods A total of 120 SD rats were randomly divided to 6 groups :group A - F ;which separately microinjected saline (group A) ,triprolidine(selective antagonist of H1 receptor ,group B) ,2‐PyEA(selective agonist of H1 receptor ,group C) ,ranitidine (selective antagonist of H2 receptor ,group D) ,dimaprit (selective agonist of H2 receptor ,group E) and histamine (group F) to the deep nuclei of rats .The abilities of rats somatic‐visceral integration were observed when hypothalamocerebellar histaminergic pro‐jections were obstructed or enhanced compared to group A .Results The somatic‐visceral integration of rats were obstructed obvi‐ously in group D and enhanced in group E & group F compared to group A ,while group B and group C had no differences compared to group A .Conclusion Hypothalamocerebellar histaminergic projections play a key role in somatic‐visceral integration through the way of H2 receptors .