A new method for determination of varicella-zoster virus immunoglobulin G avidity in serum and cerebrospinal fluid期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

A new method for determination of varicella-zoster virus immunoglobulin G avidity in serum and cerebrospinal fluid

Authors:	Ralf-Herbert?Kneitz,J?rg?Schubert,Franz?Tollmann,Wolfgang?Zens,Klaus?Hedman,Benedikt?Weissbrich author-information" > author-information__contact u-icon-before" > mailto:weissbrich@vim.uni-wuerzburg.de" title=" weissbrich@vim.uni-wuerzburg.de" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author

Affiliation:	1.Institute of Virology and Immunobiology,University of Würzburg,Würzburg,Germany;2.Dade Behring Marburg GmbH,Marburg,Germany;3.Haartman Institute, Department of Virology,University of Helsinki and Helsinki University Central Hospital (HUCH),Helsinki,Finland

Abstract:	Background Avidity determination of antigen-specific immunoglobulin G (IgG) antibodies is an established serological method to differentiate acute from past infections. In order to compare the avidity of varicella-zoster virus (VZV) IgG in pairs of serum and cerebrospinal fluid (CSF) samples, we developed a new technique of avidity testing, the results of which are not influenced by the concentration of specific IgG.

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