胡椒、荜茇对正常大鼠肝脏能量代谢因子的影响

目的:探讨热性中药胡椒、荜茇对正常大鼠肝脏能量代谢的影响,研究热性中药对大鼠生理活动的影响,为中药药性理论研究打下基础。方法:将30只大鼠随机分为3组,空白组给予生理盐水,胡椒组给予胡椒水提取液,荜茇组给予荜茇水提液,按10 mL·kg-1的量连续灌胃30 d,分别测定肝脏能量代谢相关酶类的变化。结果:与空白组比较,胡椒组、荜茇组能显著升高Ca2+-ATP酶、Ca2+-Mg2+-ATP酶以及LDH酶的活性,同时明显降低肝糖原含量,能够明显升高大鼠单位体重摄入能、消化能和可代谢能;胡椒组与荜茇组间结果比较无明显差异。结论:热性中药胡椒、荜茇能促进肝糖原的分解,增加LDH酶、Ca2+-ATP酶、Ca2+-Mg2+-ATP酶的活性,从而增加ATP酶的消耗,同时升高大鼠单位体重摄入能、消化能和可代谢能,进而促进大鼠肝脏能量代谢。

Effect of Pepper and Piper Longum on Hepatic Energy Metabolism Factors in Rats

This study was aimed to explore the effect of heat -nature Chinese herbs of Pepper and Piper longum on hepatic energy metabolism of rats in order to research the impact of rat's physical activities with heat-nature Chinese herbs and establish the research foundation of Chinese herbal medicine nature. A total of 30 rats were randomly divided into three groups. Saline was given in the control group. Pepper water extract was given in the Pepper group. And Piper longum water extract was given in the Piper longum group. The administration dosage was 10 ml/kg intragastrically for 30 days. Changes of hepatic energy metabolism related enzymes were determined. The results showed that compared with the control group, Ca2+-ATPase, Ca2+-Mg2+-ATPase, and LDH enzyme of the Pepper group and Piper longum group were significantly increased. And the hepatic glycogen content was significantly reduced. It can obviously increase energy intake, digestible energy and metabolizable energy per body weight in rats. There was no statistical significance between the Pepper group and Piper longum group. It was concluded that the heat -nature Chinese herbs of Pepper and Piper longum can promote the decomposition of hepatic glycogen, increase the activity of LDH enzyme, Ca2+-ATPase, Ca2+-Mg2+-ATPase. It increases the consumption of ATPase in order to increase energy intake, digestible energy and metabolizable energy per body weight in rats and promote the hepatic energy metabolism.