中医五行音乐改善老年及非老年肿瘤患者生存质量随机对照研究

目的:为客观评价中医五行音乐治疗对老年及非老年晚期肿瘤患者生存质量的改善作用,完善肿瘤中医综合治疗模式,方法:按随机、单盲、平行对照设计,选取晚期肿瘤患者170例,按照70岁年龄分层,并按2∶2∶1设立治疗组,耳机聆听中医五行音乐,阳性对照组耳机聆听西洋音乐,阴性对照组只戴耳机,不接受任何音乐治疗,每次30 min,每周5次,观察期为3周,收集生存质量表、KPS评分及患者填写的症状日记等结局资料。结果:从总体上看,肿瘤生活质量指数(HQOLI-R)评分,KPS和患者症状日记评分各组组内治疗前后比较,中医五行音乐组治疗前后有统计学差异(P<0.05),西洋乐和空白对照组治疗前后无统计学差异(P>0.05)。结论:无论是老年、非老年,中医五行音乐治疗均能够提高晚期肿瘤患者生活质量,改善主观症状,但对于老年肿瘤患者症状日记评分作为一种评价生活质量的指标其敏感度仍有待考证。

Randomized Controlled Trial on Effectiveness of Traditional Chinese Medicine Five Elements Music Therapy in Improving Quality of Life for Senior and Non-senior Advanced Cancer Patients

This study was aimed to evaluate effects of traditional Chinese medicine (TCM) five elements music therapy on the quality of life for both senior and non-senior advanced cancer patients, and improve TCM comprehensive treatment mode. A total of 170 patients were stratified according to 70-year-old in a randomized controlled trial (RCT) with a parallel single-blind design. The ratio of patients among three groups was 2:2:1.In the experimental group, TCM five elements music was given in the treatment. In the positive control group,western music was used in the treatment. And in the negative control group, no music was given in the treatment. The treatment was given for 30 min, 5 times per week. And the observation duration was 3 weeks. The Hospice Quality of Life Index-Revised (HQOLI-R), Karnofsky Performance Scale (KPS) and Symptom Diary Score recorded by patients were used in the evaluation. The results showed that when comparing HQOLI-R,KPS and Symptom Diary Score before and after treatment among all advanced cancer patients in each group,there was a significant difference before and after treatment in the TCM five elements music therapy group (P< 0.05). But there was no significant difference before and after treatment in the western music therapy group or the negative control group (P > 0.05). It was concluded that TCM five elements music therapy is effective in improving quality of life and subjective symptoms for both senior and non-senior advanced cancer patients.However, the sensitivity of using the Symptom Diary Score as an evaluation index among senior patients still needs to be further proved.