胎盘蛋白13和glycodelin在子痫前期患者血清中的表达

目的  探讨胎盘蛋白13（PP13）和妊娠相关子宫内膜蛋白（glycodelin）在子痫前期患者血清中的表达。方法  采用酶联免疫吸附试验（ELISA）分别测定子痫前期组（包括轻度子痫前期和重度子痫前期组）及正常妊娠妇女外周血血清中PP13、glycodelin的浓度。结果  ①子痫前期组孕妇血清PP13的水平显著高于正常妊娠组（P＜0.01），而glycodelin的水平显著低于正常妊娠组（P＜0.01）；②轻度子痫前期组PP13水平低于重度子痫前期组（P＜0.01），而轻度子痫前期与重度子痫前期组的glycodelin水平无明显差异（P＞0.05）；③PP13、glycodelin在子痫前期患者中不具有相关性；④血清PP13的水平与孕周相关。结论  子痫前期患者血清中PP13、glycodelin水平均异常表达，可能参与了子痫前期的发生，发展。同时血清PP13水平与病情的严重程度有关，可能是预测疾病进展的一项指标。

Expressions of serum placental protein 13 and glycodelin in preeclampsia

Objective  To investigate  expressions of serum placental protein 13(PP13) and glycodelin in preeclampsia. Methods  PP13 and glycodelin in peripheral blood were determined by ELISA in patients with preeclampsia（including mild preeclampsia and severe preeclampsia）and healthy controls. Results  ① The level of PP13 in the serum of the preeclampsia group was significantly higher than that of the controls（P＜0.01）, while the level of glycodelin in the serum of the preeclampsia group was significantly lower than that of the controls（P＜0.01）. ②　The level of PP13 in the serum of the mild preeclampsia group was significantly higher than that of the severe group(P＜0.01）, while the level of glycodelin in the serum of the mild preeclampsia group was not related with that of the severe group（P＞0.05）. ③　The level of PP13 was not related with the  level of glycodelin in the serum of patients with preeclampsia. ④　The level of serum PP13 correlated positively with  gestation. Conclusion  A abnormal expressions of PP13 and glycodelin may play a role in the occurrence and development of the disease. The level of serum PP13 is elevated along with the aggravated condition and may be an indicator of disease progression.