The effect of cannabinoids on the number of nuclear membrane-attached ribosomes in infant rat brain |
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| Authors: | T Hattori A Jakubovic P L McGeer |
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| Institution: | Kinsmen Laboratory of Neurological Research, Department of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver 8, B.C., Canada |
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| Abstract: | The pharmacologically active cannabinoids Δ9-THC, Δ9-THC and 11-OH-Δ9, -THC each caused a highly significant reduction in nuclear membrane-attached ribosomes of infant rat brain cells. The pharmacologically inactive agents cannabinol and cannabidiol had only a slight effect while cannabigerol had a moderate effect. The activity was measured 3 hr after a 10 mg/kg s.c. dose. The duration of effect was tested with Δ9-THC. It was significant after 1 hr, maximally developed after 3 hr, and almost completely diminished after 6 hr. |
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