ERK-dependent PSD-95 induction in the gustatory cortex is necessary for taste learning, but not retrieval |
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Authors: | Elkobi Alina Ehrlich Ingrid Belelovsky Katya Barki-Harrington Liza Rosenblum Kobi |
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Affiliation: | Center for Brain and Behavior, Department of Neurobiology and Ethology, University of Haifa, Haifa 30905, Israel. |
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Abstract: | The processes underlying long-term memory formation in the neocortex are poorly understood. Using taste learning, we found learning-related induction of PSD-95 in the gustatory cortex, which was temporally restricted, coupled to the learning of a novel, but not familiar, taste and controlled by ERK. Using temporally and spatially restricted RNA interference knockdown of PSD-95 in vivo, we found that PSD-95 induction is necessary for learning novel tastes, but not for the recollection of familiar ones. |
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