Reduction in pediatric invasive pneumococcal disease in the Basque Country and Navarre, Spain, after introduction of the heptavalent pneumococcal conjugate vaccine |
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| Authors: | J Aristegui E Bernaola I Pocheville C García L Arranz G Durán L Pérez M Bastida C Canduela M Herranz Aguirre E Garrote M A Fletcher C Pérez |
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| Institution: | (1) Pediatric Department, Basurto Hospital, Avenida Montevideo 16-18, 48013 Bilbao, Spain;(2) Pediatric Department, Virgen del Camino Hospital, Irunlarrea 4, 48013 Pamplona, Navarra, Spain;(3) Pediatric Department, Cruces Hospital, Plaza Cruces s/n, 48903 Barakalodo, Vizcaya, Spain;(4) Pediatric Department, Complejo Hospitalario Donostia, Paseo Dr. Beguiristain 109, 20014 San Sebastian, Guipuzcoa, Spain;(5) Pediatric Department, Zumárraga Hospital, Barrio Argixao s/n, 20700 Zumárraga, Guipuzcoa, Spain;(6) Pediatric Department, García Orcoyen Hospital, Santa Soria 22, 31200 Estella Navarra, Spain;(7) Pediatric Department, Txagorritxu Hospital, José Atxotegui s/n, 01009 Vitoria, Spain;(8) Pediatric Department, Santiago Apostol Hospital, Olaguibel 29, 01004 Vitoria, Spain;(9) Pediatric Department, Alto Deba Hospital, Zaldispe s/n, 20500 Mondragón, Guipuzcoa, Spain;(10) Wyeth Vaccines Research, Coeur Défense-Tour A-La Défense 4, 92931 Paris, France;(11) Wyeth Farma, Crta, N-I Km 23, Desvío Algete Km 1, 28700 San Sebastián de los Reyes, Madrid, Spain |
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| Abstract: | This study evaluated the incidence of invasive pneumococcal disease, identified the causal serotypes, and tracked the evolution
of the antibiotic susceptibility of Streptococcus pneumoniae isolates in the regions of the Basque Country and Navarre, Spain, before and after the introduction of the heptavalent pneumococcal
conjugate vaccine. The study included all children aged between birth and 5 years diagnosed with bacteremia, meningitis, or
bacteremic pneumonia caused by pneumococci. By the second year after introduction of the heptavalent pneumococcal conjugate
vaccine, compared with the period 1998–2001, the incidence of invasive disease decreased by 64.3% in children less than 12 months
of age, by 39.7% in children less than 24 months of age, and by 37.5% in children less than 60 months of age. The prevalence
of clinical isolates of S. pneumoniae that lacked susceptibility to penicillin decreased by 58.2% among children less than 60 months of age. With an estimated
coverage by four-dose heptavalent pneumococcal conjugate vaccine of 28–45% in 2003, the number of invasive pneumococcal infections
in the Basque Country and in Navarre fell significantly after just 2 years of immunization, underscoring the importance of
improving vaccination coverage under a universal childhood immunization program. |
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