Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis |
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| Authors: | Muhittin Tasdogan MD Staff Anesthesiologist Dilek Memis MD Associate Professor of Anesthesia Necdet Sut Assistant Professor of Biostatistics Mahmut Yuksel MD Associate Professor of Nuclear Medicine |
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| Institution: | aDepartment of Anaesthesiology and Reanimation, Trakya University Medical Faculty, 22030 Edirne, Turkey;bDepartment of Biostatistics, Trakya University Medical Faculty, 22030 Edirne, Turkey;cDepartment of Nuclear Medicine, Trakya University Medical Faculty, 22030 Edirne, Turkey |
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| Abstract: | Study ObjectiveTo compare the effects of an intravenous infusion of propofol and the alpha-2 adrenoceptor, dexmedetomidine, on inflammatory responses and intraabdominal pressure (IAP) in severe sepsis after abdominal surgery, specifically, serum cytokine levels (interleukin IL]-1, IL-6, and tumor necrosis factor TNF]-α) and IAP.DesignProspective, single-center study.SettingUniversity hospital.Patients40 adult ICU patients who had undergone ileus surgery and who were expected to require postoperative sedation and ventilation.InterventionsPatients received either a loading dose infusion of propofol (Group P; n = 20) one mg/kg over 15 minutes followed by a maintenance dose of one to three mg/kg/hr (n = 20, Group P) or a loading dose of dexmedetomidine of one μg/kg over 10 minutes followed by a maintenance dose of 0.2-2.5 μg/kg/h (n = 20, Group D) at the 24th hour.MeasurementsBiochemical and hemodynamic parameters, cytokine levels, and IAP were recorded before the start of the study and at the 24th and 48th hours.Main ResultsTNF-α levels were significantly lower at the 24th hour (14.66 ± 4.40 pg/mL vs. 21.21 ± 11.37 pg/mL, respectively) and at the 48th hour (21.25 ± 15.85 pg/mL vs. 46.55 ± 35.99 pg/mL, respectively) in Group D. IL-1 levels were significantly lower at the 24th hour (5.03 ± 0.15 pg/mL vs. 6.23 ± 2.09 pg/mL, respectively) and the 48th hour (5.01 ± 0.37 pg/mL vs. 6.42 ± 2.76 pg/mL, respectively) in Group D. IL-6 levels were significantly lower at the 24th hour (253.1 ± 303.6 pg/mL and 511.3 ± 374.8 pg/mL, respectively) and at the 48th hour (343.5 ± 393.4 pg/mL and 503.7 ± 306.4 pg/mL, respectively) in Group D. Intraabdominal pressure also was significantly lower at the 24th hour (12.35 ± 5.84 mmHg vs. 18.1 ± 2.84 mmHg, respectively) and the 48th hour (13.9 ± 6.15 mmHg vs. 18.7 ± 3.46 mmHg, respectively) in Group D.ConclusionDexmedetomidine infusion decreases TNF-a, IL-1, and IL-6 levels and IAP more than a propofol infusion. |
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| Keywords: | Abdominal surgery Cytokine levels Dexmedetomidine Inflammatory response Intraabdominal pressure Propofol Severe sepsis |
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